Results 191 to 200 of about 4,320,960 (307)

Genetic heterogeneity and key driver mutations in the preneoplastic and earliest stages of gastric cancer. [PDF]

Gastroenterol Rep (Oxf)
Marroquín-Estrada EA, Martínez-Gregorio H, Díaz-Velásquez CE, Ambriz-Barrera F, Córdoba-García EE, Hernández-Romero LI, Ruiz De-La-Cruz M, Cáceres A, Hernández E, Gil JR, Orellana E, Penados D, Richter C, Díaz M, Vaca-Paniagua F.   +14 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Deep genome sequencing reveals extensive genetic heterogeneity in early human placentas. [PDF]

Nat Commun
Miceikaite I, Fagerberg C, Brasch-Andersen C, Torring PM, Schlott Kristiansen B, Hao Q, Sperling L, Larsen MJ.   +7 more
europepmc   +1 more source

Intratumoral Genetic Heterogeneity

Definitions, 2020

semanticscholar   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective. [PDF]

Hum Mol Genet
Dack K, Ludwig KU, Stergiakouli E, Sandy J, Aryee S, Davey Smith G, Davies A, Wren Y, Sharp GC, Humphries K, Mangold E, Goudswaard L, Ho K, Dudding T, Lewis SJ.   +14 more
europepmc   +2 more sources

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition. [PDF]

Front Genet
Onder G, Ozdemir O, Taylan F, Canpolat C, Yalcin K, Erbey F, Sozmen BO, Asarcikli F, Bayhan T, Akcabelen YM, Yarali N, Ozbek NY, Bozkaya IO, Kacar D, Ergun B, Akkus A, Albayrak D, Ince E, Demirsoy U, Ozdemir GN, Dogru O, Aras S, Aydin E, Unal B, Amanvermez U, Dogan OA, Akyoney S, Sayitoglu M, Nordgren A, Bugra Agaoglu N, Ozbek U, Ng OH.   +31 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The Causal Pivot: A structural approach to genetic heterogeneity and variant discovery in complex diseases. [PDF]

Am J Hum Genet
Shaw CA, Williams CJ, Tan T, Illera D, Di N, Shulman JM, Belmont JW.   +6 more
europepmc   +1 more source