Results 101 to 110 of about 7,102,789 (361)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Next generation sequencing: an application in forensic sciences?
Annals of Human Biology, 2017 Context: Over the last few decades, advances in sequencing have improved greatly. One of the most important achievements of Next Generation Sequencing (NGS) is to produce millions of sequence reads in a short period of time, and to produce large ...
Maria Jesus Alvarez-Cubero +6 more
doaj +1 more source
Global Distribution of Omura’s Whales (Balaenoptera omurai) and Assessment of Range-Wide Threats
Frontiers in Marine Science, 2019 When the Omura’s whale (Balaenoptera omurai) was first described in 2003, it was known from only three locations: the southern Sea of Japan, and the vicinities of the Cocos (Keeling) Islands and Solomon Islands. Work over the following decade suggested a
Salvatore Cerchio +2 more
doaj +1 more source
Life, 2020 The systematics of many groups of organisms has been based on the adult stage. Morphological transformations that occur during development from the embryonic to the adult stage make it difficult (or impossible) to identify a juvenile (larval) stage in ...
Pedro María Alarcón-Elbal +4 more
doaj +1 more source
Identification of Genetic Markers for Prostatic Cancer Progression [PDF]
Laboratory Investigation, 2000 Despite the high incidence of prostate cancer, only limited data are available on genes or chromosomes specifically involved in its initiation and progression. We have applied comparative genomic hybridization to routinely processed, paraffin-embedded, tissues at different times in prostatic tumor progression to screen the tumor genome for gains and ...
Alers, JC (Janneke) +8 more
openaire +3 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
, 2015 Herein we provide first genetic evidence that Dreissena bugensis Andrusov, 1897 has reached the German Danube system. The occurrence of this species at several sampling sites along a 152 km river stretch of the upper Danube River thereby proved to be ...
S. Beggel +3 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Genetic Ancestry Affects the Phenotype of Normogonadotropic Anovulatory (WHOII) Subfertility [PDF]
, 2011 Introduction: Normogonadotropic (World Health Organization category II) anovulation is the most frequent cause of reduced fertility. Anovulation is associated with endocrine changes, i.e. hyperandrogenism, obesity, and insulin resistance.
Uitterlinden, André +7 more
core +1 more source