Results 141 to 150 of about 7,102,789 (361)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Monochromatic light reprograms transcription, metabolism, and rhizosphere microbial communities in Salvia miltiorrhiza

Plant Signaling & Behavior
Salvia miltiorrhiza is a valuable medicinal plant with diverse pharmacological applications and high market demand. Light quality is a critical environmental factor regulating plant growth, secondary metabolism, and interactions with rhizosphere ...
Xiaoyan Chen, Shuxian Ding, Huan Tang, Qing Yang, Langxing Yuan, Aling Zhang, Yingying Li, Qinglong Wang, Xiaoxia Yan, Zhunian Wang, Maoyuan Wang, Zai Zheng   +11 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Characterisation of the Latvian and Swedish Sweet and Sour Cherry Genetic Resources [PDF]

, 2010
A wide diversity of cherry varieties are collected in the Latvian and Swedish genetic resources collections, which consists of landraces and selections of local breeders, adapted to the local climate and growing conditions (winter hardy and disease ...
Lacis, Gunars
core  

A tiling1deletion based genetic screen for cis-regulatory element identification in mammalian cells

Nature Methods, 2017
Millions of cis-regulatory elements are predicted to be present in the human genome, but direct evidence for their biological function is scarce. Here we report a high-throughput method, cis-regulatory element scan by tiling-deletion and sequencing ...
Yarui Diao, Rongxin Fang, Bin Li, Z. Meng, Juntao Yu, Yunjiang Qiu, Kimberly C. Lin, Hui Huang, Tristin Liu, Ryan J. Marina, Inkyung Jung, Yin Shen, K. Guan, B. Ren   +13 more
semanticscholar   +1 more source

Probabilistic genetic identification of wild boar hybridization to support control of invasive wild pigs (Sus scrofa)

Ecosphere
The rapid expansion of wild pigs (Sus scrofa) throughout the United States has been fueled by unlawful introductions, with invasive populations causing extensive crop losses, damaging native ecosystems, and serving as a reservoir for disease.
Timothy J. Smyser, Peter Pfaffelhuber, Rachael M. Giglio, Matthew G. DeSaix, Amy J. Davis, Courtney F. Bowden, Michael A. Tabak, Arianna Manunza, Valentin Adrian Bâlteanu, Marcel Amills, Laura Iacolina, Pamela Walker, Carl Lessard, Antoinette J. Piaggio   +13 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Genetic diversity and genetic differentiation in Echinococcus granulosus (Batsch, 1786) from domestic and sylvatic hosts on the mainland of Australia [PDF]

, 1990
Enzyme electrophoresis was used to examine genetic variation within and between populations of Echinococcus granulosus from domestic and sylvatic hosts in western and eastern Australia.
Hobbs, R.P., Thompson, R.C.A., Lymbery, A.J.   +2 more
core   +1 more source

A multiplex (m)RNA-profiling system for the forensic identification of body fluids and contact traces [PDF]

, 2012
In current forensic practice, information about the possible biological origin of forensic traces is mostly determined using protein-based presumptive testing.
Sijen, T, de Pagter, M, Lindenbergh, A, Ramdayal, G, Visser, Mijke, Kayser, Manfred, Zubakov, Dmitry   +6 more
core   +1 more source

Identification of 12 genetic loci associated with human healthspan

Communications Biology, 2018
Aging populations face diminishing quality of life due to increased disease and morbidity. These challenges call for longevity research to focus on understanding the pathways controlling healthspan.
A. Zenin, Y. Tsepilov, S. Sharapov, E. Getmantsev, L. Menshikov, P. Fedichev, Y. Aulchenko   +6 more
semanticscholar   +1 more source