Results 11 to 20 of about 99,336 (255)
Genetics and epigenetics in obesity [PDF]
Metabolism, 2019 Obesity is among the most threatening health burdens worldwide and its prevalence has markedly increased over the last decades. Obesity maybe considered a heritable trait. Identifications of rare cases of monogenic obesity unveiled that hypothalamic circuits and the brain-adipose axis play an important role in the regulation of energy homeostasis ...
Rohde, Kerstin +5 more
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Genetics, Epigenetics, and Leukemia [PDF]
New England Journal of Medicine, 2010 In this issue of the Journal, Ley and colleagues1 report that somatic mutations in a gene encoding a DNA methyltransferase, DNMT3A, are common in adults with acute myeloid leukemia (AML). They also report that these mutations are associated with discrete molecular and cytogenetic features that have prognostic significance.
Kevin, Shannon, Scott A, Armstrong
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Mitochondrial Genetics and Epigenetics in Osteoarthritis [PDF]
Frontiers in Genetics, 2020 During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial genetic polymorphisms, specifically the mitochondrial DNA haplogroups, have been shown to have an important influence on different OA-related ...
Rego-Pérez, I. +3 more
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Genetics and Epigenetics of Parathyroid Carcinoma [PDF]
Frontiers in Endocrinology, 2022 Parathyroid carcinoma (PC) is an extremely rare malignancy, accounting less than 1% of all parathyroid neoplasms, and an uncommon cause of primary hyperparathyroidism (PHPT), characterized by an excessive secretion of parathyroid hormone (PTH) and severe hypercalcemia.
Francesca Marini +6 more
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Genetics and epigenetics of melanoma
Oncology Letters, 2016 Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research.
Zhang, Xiao-Ying, Zhang, Pei-Ying
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Timescales of Genetic and Epigenetic Inheritance [PDF]
Cell, 2007 According to classical evolutionary theory, phenotypic variation originates from random mutations that are independent of selective pressure. However, recent findings suggest that organisms have evolved mechanisms to influence the timing or genomic location of heritable variability.
Rando, Oliver J., Verstrepen, Kevin
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The genetics and epigenetics of satellite centromeres
Genome Research, 2021 Centromeres, the chromosomal loci where spindle fibers attach during cell division to segregate chromosomes, are typically found within satellite arrays in plants and animals. Satellite arrays have been difficult to analyze because they comprise megabases of tandem head-to-tail highly repeated DNA sequences.
Paul B. Talbert, Steven Henikoff
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Genetics and epigenetics of obesity
Maturitas, 2011 Obesity results from interactions between environmental and genetic factors. Despite a relatively high heritability of common, non-syndromic obesity (40-70%), the search for genetic variants contributing to susceptibility has been a challenging task. Genome wide association (GWA) studies have dramatically changed the pace of detection of common genetic
Herrera, Blanca M. +2 more
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Genetics and epigenetics of IBD
Pharmacological Research, 2020 Inflammatory bowel diseases (IBD) are chronic intermittent inflammatory disorders of the gastrointestinal tract of unknown etiology but a clear genetic predisposition. Prompted by the first investigations on IBD families and twins, the genetic and epigenetic studies have produced an unprecedented amount of information in comparison with other immune ...
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Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD) [PDF]
, 2018 Genetics and epigenetics play a key role in the development of several diseases, including nonalcoholic fatty liver disease (NAFLD). Family studies demonstrate that first degree relatives of patients with NAFLD are at a much higher risk of the disease ...
Campo, José Antonio del +3 more
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