Results 41 to 50 of about 55,739 (324)
Interplay between Epigenetics and Genetics in Cancer [PDF]
Genomics & Informatics, 2013 Genomic instability, which occurs through both genetic mechanisms (underlying inheritable phenotypic variations caused by DNA sequence-dependent alterations, such as mutation, deletion, insertion, inversion, translocation, and chromosomal aneuploidy) and
Jae Duk Choi, Jong-Soo Lee
doaj +1 more source
Scientific Reports, 2021 Tumor development involves alterations in DNA methylation patterns, which include both gains (hypermethylation) and losses (hypomethylation) in different genomic regions.
Jean S. Fain +4 more
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Can genetics guide exercise prescriptions in osteoarthritis?
Frontiers in Rehabilitation Sciences, 2022 Osteoarthritis (OA) is the most common form of arthritis and has a multifactorial etiology. Current management for OA focuses on minimizing pain and functional loss, typically involving pharmacological, physical, psychosocial, and mind-body interventions.
Osvaldo Espin-Garcia +8 more
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Timescales of Genetic and Epigenetic Inheritance [PDF]
Cell, 2007 According to classical evolutionary theory, phenotypic variation originates from random mutations that are independent of selective pressure. However, recent findings suggest that organisms have evolved mechanisms to influence the timing or genomic location of heritable variability.
Rando, Oliver J., Verstrepen, Kevin
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2022 Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent need to advance research on its phenomenology and etiology. Epidemiological studies have demonstrated that suicidal behavior is heritable, suggesting that genetic ...
Salahudeen Mirza +6 more
semanticscholar +1 more source
Genetics and epigenetics of liver cancer [PDF]
New Biotechnology, 2013 Hepatocellular carcinoma (HCC) represents a major form of primary liver cancer in adults. Chronic infections with hepatitis B (HBV) and C (HCV) viruses and alcohol abuse are the major factors leading to HCC. This deadly cancer affects more than 500,000 people worldwide and it is quite resistant to conventional chemo- and radiotherapy.
Ozen, C. +7 more
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Male breast cancer: genetics, epigenetics, and ethical aspects [PDF]
, 2013 Background and study design: Male breast cancer (MBC) is a rare disease compared with female BC and our current understanding regarding breast carcinogenesis in men has been largely extrapolated from the female counterpart.
FRATI, PAOLA +26 more
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Genetics and epigenetics of melanoma
Oncology Letters, 2016 Cancer affects multiple organs in the body Malignant melanoma involves the invasion of skin and occasionally mucosal membrane or eye choroidal tissues. The incidence of cutaneous malignant melanoma is on the increase worldwide and is a major concern in current research.
Zhang, Xiao-Ying, Zhang, Pei-Ying
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, 2021 Alcohol use disorder (AUD) is a very common and complex disease, as alcohol is the most widely used addictive drug in the world. This disorder has an enormous impact on public health and social and private life, and it generates a huge number of social ...
Agnieszka Siomek-Gorecka +2 more
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Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.
, 2022 In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers increased risk for neurodevelopmental disorders, cardiovascular disease, and ...
Vidal, Adriana C +13 more
core +1 more source