Results 21 to 30 of about 99,336 (255)

Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma [PDF]

, 2016
Background: Cytology-based screening methods for cervical adenocarcinoma (ADC) and to a lesser extent squamous-cell carcinoma (SCC) suffer from low sensitivity.
Boers, Aniek, De Meyer, Tim, Klip, Harry G, Schuuring, Ed, Steenbergen, Renske DM, Van Criekinge, Wim, van der Zee, Ate GJ, van Leeuwen, Robert W, Wang, Rong, Wisman, G Bea A   +9 more
core   +2 more sources

Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes. [PDF]

, 2017
Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics analysis to evaluate the utility
A Brazma, A Nan, A Okuhara, A Turchinovich, B Aryal, B Mayr, B Sharif, B Zhang, BM Bolstad, BM Kuhn, BM Mayr, C Beyer, C Chen, C Guay, C Taurino, CL Andersen, D Dlouha, D Iliopoulos, D Zhang, DT Felson, F Kostopoulou, FE Nicolas, G Dennis Jr, G Li, G Tardif, GD Miles, GR Sondag, GS Lien, H Causton, JB van Meurs, JD Storey, JD Storey, KC Vickers, L Qi, M Cross, M Parrizas, MB Goldring, MC Hochberg, MD Paraskevopoulou, MP Gantier, OF Laterza, Q Zhuo, R Gernapudi, RF Loeser, RI Gregory, S Kluzek, S Kumar, S Miyaki, T Thomou, TA Karlsen, VM Borgonio Cuadra, W Cleveland, WM Reichmann, X Chen, X Chen, X Tan, X Wang, Y Klipper-Aurbach, Y Zhang, YH Li   +59 more
core   +2 more sources

Genetics and epigenetics of liver cancer [PDF]

New Biotechnology, 2013
Hepatocellular carcinoma (HCC) represents a major form of primary liver cancer in adults. Chronic infections with hepatitis B (HBV) and C (HCV) viruses and alcohol abuse are the major factors leading to HCC. This deadly cancer affects more than 500,000 people worldwide and it is quite resistant to conventional chemo- and radiotherapy.
Ozen, C., Yildiz G., Dagcan, A.T., Cevik, D., Ors, A., Keles, U., Topel H., Ozturk, M.   +7 more
openaire   +5 more sources

A new target for differentiation therapy in AML [PDF]

, 2016
Despite major advances in understanding the genetics and epigenetics of acute myelogenous leukemia, there is still a great need to develop more specific and effective therapies.
Hess, Jay L, Ma, Peilin, Song, Weihua
core   +1 more source

Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity. [PDF]

, 2017
BackgroundThe study of epigenetic processes and mechanisms present a dynamic approach to assess complex individual variation in obesity susceptibility. However, few studies have examined epigenetic patterns in preschool-age children at-risk for obesity ...
Barkin, Shari L, Guo, Yan, Non, Amy L, Oelsner, Kathryn Tully, To, Sophie Bao-Chieu   +4 more
core   +2 more sources

Genetics, epigenetics, and pregenetics

International Journal of Yoga, 2011
Byline: Thaiyar. Srinivasan In the blame game of genetic disorders, genes are credited with the disrupting lives of millions of people around the world. The disruption of any system in the body is blamed as a bad gene effect. Genetics ruling lives of living systems is a Darwinian hangover.
openaire   +3 more sources

Genetics and Epigenetics of Atrial Fibrillation [PDF]

International Journal of Molecular Sciences, 2020
Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting up to 1% of the general population. Its prevalence exponentially increases with age and could reach up to 8% in the elderly population. The management of AF is a complex issue that is addressed by extensive ongoing basic and clinical research.
Estefanía Lozano-Velasco, Diego Franco, Amelia Aranega, Houria Daimi   +3 more
openaire   +3 more sources

Genetics and epigenetics of Alzheimer's disease [PDF]

Postgraduate Medical Journal, 2012
Abstract Alzheimer's disease (AD) is a highly prevalent condition that predominantly affects older adults. AD is a complex multifactorial disorder with a number of genetic, epigenetic and environmental factors which ultimately lead to premature neuronal death. Predictive and susceptibility genes play a role in AD. Early-onset familial AD
Kannayiram, Alagiakrishnan, Sudeep S, Gill, Andrei, Fagarasanu   +2 more
openaire   +2 more sources

Crossovers between epigenesis and epigenetics. A multicenter approach to the history of epigenetics (1901-1975) [PDF]

, 2014
The origin of epigenetics has been traditionally traced back to Conrad Hal Waddington's foundational work in 1940s. The aim of the present paper is to reveal a hidden history of epigenetics, by means of a multicenter approach.
Costa, R., Frezza, G.
core  

Environment, epigenetics and neurodegeneration: Focus on nutrition in Alzheimer's disease [PDF]

, 2015
Many different environmental factors (nutrients, pollutants, chemicals, physical activity, lifestyle, physical and mental stress) can modulate epigenetic markers in the developing and adult organism. Epigenetics, in turn, can cause and is associated with
FUSO, ANDREA, LUCARELLI, Marco, NICOLIA, Vincenzina   +2 more
core   +3 more sources