Results 41 to 50 of about 100,181 (178)
Nature Communications, 2018 Transcription-replication conflicts need to be resolved to minimize genome instability. Here the authors show that SUMO2-conjugated PCNA destabilizes RNAPII from chromatin, enhances replication progression and limits transcription-induced DNA damage at ...
Min Li +5 more
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Timescales of Genetic and Epigenetic Inheritance [PDF]
Cell, 2007 According to classical evolutionary theory, phenotypic variation originates from random mutations that are independent of selective pressure. However, recent findings suggest that organisms have evolved mechanisms to influence the timing or genomic location of heritable variability.
Rando, Oliver J., Verstrepen, Kevin
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Inflammatory Bowel Disease: Genetics, Epigenetics and Pathogenesis
Frontiers in Immunology, 2015 Inflammatory Bowel Diseases (IBDs) are complex, multifactorial disorders characterized by chronic relapsing intestinal inflammation. Although aetiology remains largely unknown, recent research has suggested that genetic factors, environment, microbiota ...
Italia eLoddo, Claudio eRomano
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Journal of Plant Interactions, 2020 WDR proteins in plants regulate multiple aspects of plant growth and development, as well as plant responses to environmental stimuli. Here, we report the identification of AIW1 (ABA-induced WD40-repeat 1) and AIW2 as novel regulators of salt responses ...
Xutong Wang +12 more
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Methylation of the Vitamin D Receptor (VDR) Gene, Together with Genetic Variation, Race, and Environment Influence the Signaling Efficacy of the Toll-Like Receptor 2/1-VDR Pathway [PDF]
, 2017 BackgroundThe disparity in prevalence of infectious diseases across the globe is common knowledge. Vitamin D receptor (VDR)-mediated toll-like receptor (TLR) 2/1 signaling produces antimicrobial peptides, which is critical as a first line of defense in ...
Abhimanyu +46 more
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Obesity Genetics and Epigenetics [PDF]
Circulation: Cardiovascular Genetics, 2014 Genome-wide association studies (GWAS) have successfully revealed multiple obesity-associated genetic loci1. A strong reproducible signal comes from a cluster of the variants that lie in the 47-kb region of the first and second intron of fat mass and obesity associated ( FTO ) gene2,3. Each copy of the risk allele of FTO variants is associated with a 1.
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Genetics and epigenetics of liver cancer [PDF]
New Biotechnology, 2013 Hepatocellular carcinoma (HCC) represents a major form of primary liver cancer in adults. Chronic infections with hepatitis B (HBV) and C (HCV) viruses and alcohol abuse are the major factors leading to HCC. This deadly cancer affects more than 500,000 people worldwide and it is quite resistant to conventional chemo- and radiotherapy.
Ozen, C. +7 more
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Public Health GenomicsIntroduction: Accumulating evidence suggests that preconception epigenetic changes elevate the risk for obesity throughout the lifespan. Little is known about how parents may react to learning about parent-child epigenetic transmission of ...
Emma M. Schopp +3 more
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NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics
Frontiers in Oncology, 2022 Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, poorly differentiated carcinoma occurring mostly in adolescents and young adults.
Vanessa Moreno +2 more
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DNMTs are required for delayed genome instability caused by radiation [PDF]
, 2012 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, RM +10 more
core +2 more sources