Synthesizing efficacious genistein in conjugation with superparamagnetic Fe3O4 decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma [PDF]
, 2020 Background Genistein (C15H10O5) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range.
Ghasemi Goorbandi, Rachel +2 more
core +3 more sources
Genistein-induced mir-23b expression inhibits the growth of breast cancer cells [PDF]
, 2015 Aim of the study: Genistein, an isoflavonoid, plays roles in the inhibition of protein tyrosine kinase phosphorylation, induction of apoptosis, and cell differentiation in breast cancer.
Avci, C.B. +6 more
core +2 more sources
Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer. [PDF]
, 2011 Genistein is an isoflavone found in soy, and its chemo-preventive and -therapeutic effects have been well established from in vitro studies. Recently, however, its therapeutic actions in vivo have been questioned due to contradictory reports from animal ...
Adomat, Hans +5 more
core +4 more sources
Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals. [PDF]
, 2009 CXCR4 is a chemokine receptor frequently overexpressed on primary tumor cells. Organs to which these cancers metastasize secrete CXCL12, the unique ligand for CXCR4, which stimulates invasion and metastasis to these sites.
Chen, Natalie +6 more
core +4 more sources
, 2004 Collectively, plants contain several different families of natural products among which are compounds with weak estrogenic or antiestrogenic activity toward mammals.
Adlercreutz H +37 more
core +1 more source
FMO Study of the Interaction Energy between Human Estrogen Receptor $α$ and Selected Ligands [PDF]
arXiv, 2022 Fragment molecular orbital (FMO) calculations were performed in aqueous media which allowed us to obtain the interaction energy between the human estrogen receptor $\alpha$ ligand-binding domain (ER) and the selected ligands (L): 17$\beta$-estradiol (E2), 17$\alpha$-estradiol (17$\alpha$-E2), estriol (E3), genistein (GNT), diethylstilbestrol (DES ...
arxiv
The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction [PDF]
, 2016 Gene therapy has long been regarded as a promising treatment for cancer. However, cancer gene therapy is still facing the challenge of targeting gene delivery vectors specifically to tumors when administered via clinically acceptable non-invasive ...
Albahrani, M +5 more
core +2 more sources
The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells [PDF]
, 2017 open12noBreast cancer (BC) is one of the major causes of cancer death in women and is closely related to hormonal dysregulation. Estrogen receptor (ER)-positive BCs are generally treated with anti hormone therapy using antiestrogens or aromatase ...
CARRA, Serena +11 more
core +3 more sources
The Association Between Urinary Genistein Levels and Mortality Among Adults in the United States [PDF]
, 2019 BackgroundCurrent research on the relationship between phytoestrogens and mortality has been inconclusive. We explored the relationship between genistein, a phytoestrogen, and mortality in a large cohort representative of the United States population ...
Marcelo, Carolyn +3 more
core +2 more sources
Preliminary investigation of the influence of long-term dietary isoflavone intake on reproductive tract histology and sex steroid receptor expression in female domestic cats (Felis catus) [PDF]
, 2012 Genistein and daidzein are isoflavones which are reported to influence the reproductive system in a variety of mammalian species. This pilot study aimed to determine if dietary isoflavones could potentially influence reproductive tract histology or ...
Cave, NJ +4 more
core +1 more source