Results 1 to 10 of about 31,152 (194)

Eudragit nanoparticles containing genistein: formulation, development, and bioavailability assessment

International Journal of Nanomedicine, 2011
Jingling Tang2, Na Xu1,2, Hongyu Ji1, Hongmei Liu1, Zhiyong Wang1, Linhua Wu1,2 1Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Key Laboratory of College in Heilongjiang Province; 2Department of Pharmaceutics, School
Tang J, Xu N, Ji H, Liu H, Wang Z, Wu L
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Genistein and Curcumin Inhibit Proliferation and Invasiveness in BRAFV600E Mutant and Wild-Type Melanoma Cells: Insights into Their Anticancer Effects [PDF]

Biomedicines
Background/objectives: Melanoma is one of the deadliest forms of malignant cancers; ultraviolet radiation exposure together with genetic mutations, such as BRAF, represent the main risk factors and are involved in metastatic dissemination.
Federico Vaccaro, Federica Mannino, Mariacarmela Santarpia, Chiara Cullotta, Mariarosaria Galeano, Francesco Borgia, Federica Li Pomi, Vincenzo Arcoraci, Maria Lentini, Mariausilia Franchina, Mario Vaccaro, Giovanni Pallio, Natasha Irrera   +12 more
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Genistein enhances anti-PD-1 efficacy in melanoma by suppressing regulatory T cell differentiation and activity [PDF]

Scientific Reports
The accumulation of regulatory T cells (Tregs) in the tumor microenvironment is a key factor for immunosuppression and immune escape of cancer cells.
Fei Mo, Min Hong, Xiao Chen, Qiye Wang, Chao Dong   +4 more
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Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2009
Background Vasculogenic mimicry (VM) was increasingly recognized as a form of aggressive melanoma acquiring blood supply. Genistein had attracted much attention as a potential anticancer agent.
Gu Haijuan, Yang Li, Sun Qingmin, Cong Rihong, Zeng Ying, Wang Bin   +5 more
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Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line. [PDF]

PLoS ONE, 2012
Genistein (GEN) is a plant-derived isoflavone and can block uncontrolled cell growth in colon cancer by inhibiting the WNT signaling pathway. This study aimed to test the hypothesis that the enhanced gene expression of the WNT signaling pathway ...
Huan Wang, Qian Li, Hong Chen
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The Anticancer Effect of Genistein Through Enhancing PERK Signaling and Suppressing the IRE1α-XBP1 Axis in Canine Mammary Gland Tumor Cells [PDF]

Animals
Genistein, a natural isoflavone, exerts anticancer effects on human breast cancer cells by modulating the unfolded protein response (UPR). However, the effect of genistein on UPR in canine mammary gland tumor (CMT) cells remains unknown.
Ye-Ji Jang, Min-Jae Yoo, Hyuk Jang, Jun Song, Sang-Youel Park, Jawun Choi, Jae-Won Seol   +6 more
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Effects of genistein on glucose and lipid metabolism of common carp (Cyprinus carpio. L) in vivo and in vitro

Aquaculture Reports, 2022
Genistein exhibits anti-diabetic and anti-lipogenic effects in mammals, however, there are rare reports on the effects of genistein on glucose and lipid metabolism in fish.
Liping Yang, Wenlei Zhang, Shaoyang Zhi, Mingyu Liu, Mengjuan Zhao, Chaobin Qin, Xiao Yan, Junchang Feng, Guoxing Nie   +8 more
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Co-treatment With Everolimus, an mTOR-Specific Antagonist, or Downregulation of ELK1 Enhances the Sensitivity of Pancreatic Cancer Cells to Genistein

Frontiers in Cell and Developmental Biology, 2021
Genistein is a natural isoflavone with pharmacological or potentially anti-tumor properties. However, the resistance of cancer cells to genistein remains a major obstacle.
Tianyu Li, Tiantao Kuang, Zhaoshuo Yang, Qiqi Zhang, Wen Zhang, Yue Fan, Yue Fan   +6 more
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Genistein Inhibits Proliferation and Metastasis in Human Cervical Cancer Cells through the Focal Adhesion Kinase Signaling Pathway: A Network Pharmacology-Based In Vitro Study in HeLa Cells

Molecules, 2023
Previous studies have provided evidence that genistein exerts a therapeutic effect on different tumor cells. However, the mechanism of action of genistein against cervical cancer cells remains largely unknown. The aim of this study was to comprehensively
Tingting Chen, Juan Wang, Min Li, Qingqing Wu, Shuna Cui   +4 more
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The Role of Genistein in Mammalian Reproduction

Molecules, 2023
Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen.
Gabriella Guelfi, Rolando Pasquariello, Polina Anipchenko, Camilla Capaccia, Georgia Pennarossa, Tiziana A. L. Brevini, Fulvio Gandolfi, Massimo Zerani, Margherita Maranesi   +8 more
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