Results 11 to 20 of about 31,152 (194)
Inhibition of castration-resistant prostate cancer growth by genistein through suppression of AKR1C3
Food & Nutrition Research, 2023 Background: Prostate cancer is the second leading cause of cancer-related death among males in America. The patients’ survival time is significantly reduced after prostate cancer develops into castration-resistant prostate cancer (CRPC).
Xiaoping Yu +6 more
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Nutrikinetic study of genistein metabolites in ovariectomized mice. [PDF]
PLoS ONE, 2017 This study was designed to evaluate the effect of ovariectomy on nutrikinetics of genistein metabolites. To characterize the time-dependent changes in genistein metabolite concentrations, we identified 13 genistein metabolites using ultra-performance ...
Da-Hye Lee +8 more
doaj +1 more source
Frontiers in Nutrition, 2022 IntroductionInsulin signaling via the insulin receptor (IR) may be associated with the amelioration of diet-induced metabolic syndrome. Genistein, a soy isoflavone, has been suggested to play a role in the amelioration of high-fat diet-induced metabolic ...
Nana Zhang +6 more
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Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein
Neural Regeneration Research, 2018 Genistein, a potent antioxidant compound, protects dopaminergic neurons in a mouse model of Parkinson's disease. However, the mechanism underlying this action remains unknown.
Huan-Cheng Wu +9 more
doaj +1 more source
Redox Report, 2022 Objective Genistein is a recognized isoflavone present in soybeans with antioxidant, anti-inflammatory, antiangiogenic and antitumor activities. This study aimed to test ability of genistein in modulating versican/platelet derived growth factor (PDGF ...
Yousra M. El-Far +4 more
doaj +1 more source
Involvement of Caspase-3 Pathway in Anti-cancer Properties of Genistein in AGS Gastric Cancer Cell Line is Still Enigmatic [PDF]
Avicenna Journal of Medical Biochemistry, 2022 Background: Genistein is an isoflavone that has been reported to have various anti-cancer properties. Objectives: This study aimed to reveal whether or not the anti-cancer properties of genistein in AGS gastric cancer cell line were mediated through ...
Neda Ghasemkhani +4 more
doaj +1 more source
Direct Identification and Quantification of Flavonoids and Their Structural Isomers Using Ambient Ionization Tandem Mass Spectrometry. [PDF]
Rapid Commun Mass SpectromABSTRACT Rationale Flavonoids are phenolic compounds with many health‐benefiting properties. However, differentiating different types of flavonoids and their isomers is challenging due to their highly similar structures of various subtypes and different numbers and sites of substituents.
Wang Y, Xu L, Gu T, Li H, Chen DDY.
europepmc +2 more sources
Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2
Food & Nutrition Research, 2016 Background: Genistein has been proved in vitro and in vivo to lower LDLR level. It is also widely consumed and implicated for its anti-atherogenic effects.
Medicia Kartawijaya +3 more
doaj +1 more source
Antioxidants, 2019 We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest of the cell cycle and apoptosis.
Cheol Park +12 more
doaj +1 more source
Formation of phosphoglycosides in Caenorhabditis elegans: a novel biotransformation pathway. [PDF]
PLoS ONE, 2012 BACKGROUND: Caenorhabditis elegans (C. elegans) has become a widely used model to explore the effect of food constituents on health as well as on life-span extension.
Sebastian T Soukup +5 more
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