Results 211 to 220 of about 2,011,170 (298)

Author Correction: MOADE: a multimodal autoencoder for dissociating bulk multi-omics data. [PDF]

Genome Biol
Sun J, Malik AA, Lin T, Bratton A, Pan Y, Smith K, Onar-Thomas A, Robinson GW, Zhang W, Northcott PA, Li Q.   +10 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

A closed-loop method for precise genome size estimation using HiFi reads. [PDF]

BMC Genomics
Xing J, Hao J, Tang C, Xie S, Liu K.
europepmc   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Comparative genomics of Shiga toxin-producing <i>Escherichia coli</i> reveals host-specific adhesiome adaptations in humans and cattle. [PDF]

Front Vet Sci
Martínez V, Cartajena JT, Méndez E, Dörner J, Méndez D, Arriagada G, Toledo J, Arancibia R, Pizarro N, Castro D, Luna D, Ramos R, Jorquera J, Escobar B, Kudva IT, Galarce N.   +15 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Beyond single references: pangenome graphs and the future of genomic medicine. [PDF]

Front Genet
Nyaga DM, Zaied RE, Silander OK, Black MA, O'Sullivan JM.   +4 more
europepmc   +1 more source

Human genome dispute [PDF]

Nature, 1991
openaire   +3 more sources

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

APOBEC3A drives deaminase mutagenesis in human gastric epithelium. [PDF]

Genome Res
An Y, Lee JH, Lim J, Youk J, Park S, Park JH, Yi K, Kim T, Nam CH, Lee WH, Oh SA, Bae YJ, Klompstra TM, Lee H, Han J, Lee J, Park JW, Kim JH, Kim H, Snippert H, Koo BK, Ju YS.   +21 more
europepmc   +1 more source