Results 81 to 90 of about 10,877,278 (223)
Dynamic disequilibrium-based pathogenicity model in mutated pyrin’s B30.2 domain—Casp1/p20 complex
Journal of Genetic Engineering and Biotechnology, 2022 Background The B30.2 variants lead to most relevant severity forms of familial Mediterranean fever (FMF) manifestations. The B30.2 domain plays a key role in protein-protein interaction (PPI) of pyrin with other apoptosis proteins and in regulation the ...
Alaaeldin G. Fayez +10 more
doaj +1 more source
Heredity, 2003 The Human Genome is a beautifully assembled and well-written publication, enriched with high-quality photographs and diagrams that will appeal to both students and professional scientists and educators. This seven-chapter book begins with an appropriate foreword by Nobel laureate James Watson, the codiscoverer of the structure of DNA.
openaire +1 more source
Large-scale discovery of enhancers from human heart tissue. [PDF]
, 2011 Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers.
Afzal, Veena +16 more
core
npj MicrogravityThe surge in commercial and civilian spaceflight enables the systematic and longitudinal, large-scale biospecimen collection to understand the prospective effects of space travel on human health.
Aparna Krishnavajhala +17 more
doaj +1 more source
Search-and-replace genome editing without double-strand breaks or donor DNA
Nature, 2019 Most genetic variants that contribute to disease1 are challenging to correct efficiently and without excess byproducts2–5. Here we describe prime editing, a versatile and precise genome editing method that directly writes new genetic information into a ...
Andrew V. Anzalone +10 more
semanticscholar +1 more source
Alzheimer's disease and HIV associated dementia related genes: I. location and function. [PDF]
, 2008 Alzheimer's disease (AD), the most common cause of dementia, has few clinical similarities to HIV-1-associated dementia (HAD). However, genes were identified related among these dementias.
Chiappelli, Francesco +5 more
core +3 more sources
The accessible chromatin landscape of the human genome
Nature, 2012 DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions.
R. Thurman +58 more
semanticscholar +1 more source
An integrated 4249 marker FISH/RH map of the canine genome [PDF]
, 2004 BACKGROUND: The 156 breeds of dog recognized by the American Kennel Club offer a unique opportunity to map genes important in genetic variation. Each breed features a defining constellation of morphological and behavioral traits, often generated by ...
André, Catherine +17 more
core +3 more sources
Changes in H3K27ac following lipopolysaccharide stimulation of nasopharyngeal epithelial cells
BMC Genomics, 2018 Background The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such
Lisa Borghini +2 more
doaj +1 more source
A human gut bacterial genome and culture collection for improved metagenomic analyses
Nature Biotechnology, 2019 Understanding gut microbiome functions requires cultivated bacteria for experimental validation and reference bacterial genome sequences to interpret metagenome datasets and guide functional analyses.
S. Forster +17 more
semanticscholar +1 more source