Results 11 to 20 of about 1,052,313 (231)
The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates☆ [PDF]
International Journal for Parasitology, 2017 Vaccine development targeting protozoan parasites remains challenging, partly due to the complex interactions between these eukaryotes and the host immune system. Reverse vaccinology is a promising approach for direct screening of genome sequence assemblies for new vaccine candidate proteins.
N. Palmieri +7 more
semanticscholar +6 more sources
CRISPR/Cas9 Ribonucleoprotein-Based Genome Editing Methodology in the Marine Protozoan Parasite Perkinsus marinus [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Perkinsus marinus (Perkinsozoa), a close relative of apicomplexans, is an osmotrophic facultative intracellular marine protozoan parasite responsible for “Dermo” disease in oysters and clams.
Raghavendra Yadavalli +11 more
doaj +3 more sources
Nanopore Sequencing Significantly Improves Genome Assembly of the Protozoan Parasite Trypanosoma cruzi [PDF]
Genome Biology and Evolution, 2019 Chagas disease was described by Carlos Chagas, who first identified the parasite Trypanosoma cruzi from a 2-year-old girl called Berenice. Many T. cruzi sequencing projects based on short reads have demonstrated that genome assembly and downstream ...
F. Díaz-Viraqué +5 more
semanticscholar +4 more sources
Genomes and genome projects of protozoan parasites. [PDF]
Current Issues in Molecular Biology, 2003 Protozoan parasites are causing some of the most devastating diseases world-wide. It has now been recognised that a major effort is needed to be able to control or eliminate these diseases.
K. Ersfeld
semanticscholar +3 more sources
Single-cell genome sequencing of protozoan parasites.
Trends in Parasitology, 2021 Despite considerable genetic variation within hosts, most parasite genome sequencing studies focus on bulk samples composed of millions of cells. Analysis of bulk samples is biased toward the dominant genotype, concealing cell-to-cell variation and rare variants.
A. Dia, Ian H. Cheeseman
semanticscholar +3 more sources
Species diversity and genome evolution of the pathogenic protozoan parasite, Neospora caninum. [PDF]
Infection, Genetics and Evolution, 2020 Neospora caninum is a cyst-forming coccidian parasite of veterinary and economical significance, affecting dairy and beef cattle industries on a global scale. Comparative studies suggest that N. caninum consists of a globally dispersed, diverse population of lineages, distinguished by their geographical origin, broad host range, and phenotypic features.
Larissa Calarco, J. Ellis
semanticscholar +3 more sources
PLOS Neglected Tropical Diseases, 2019 Babesiosis is considered an emerging disease because its incidence has significantly increased in the last 30 years, providing evidence of the expanding range of this rare but potentially life-threatening zoonotic disease.
L. González +12 more
semanticscholar +7 more sources
Genomics, 2014 Leishmania donovani is a kinetoplastid protozoan parasite which causes the fatal disease visceral leishmaniasis in humans. Genome sequencing of L. donovani revealed information about the arrangement of genes and genome architecture. After curation of the genome sequence, many genes in L.
Harsh Pawar +4 more
semanticscholar +3 more sources
Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]
, 2012 The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant +85 more
core +14 more sources
Protozoan genomics for drug discovery [PDF]
Nature Biotechnology, 2005 Comparing the metabolic pathways of parasites and their hosts facilitates the identification of new drug targets.
Chaudhary, Kshitiz, Roos, David S
openaire +1 more source