Results 31 to 40 of about 70 (69)
Genomics, 2014 Leishmania donovani is a kinetoplastid protozoan parasite which causes the fatal disease visceral leishmaniasis in humans. Genome sequencing of L. donovani revealed information about the arrangement of genes and genome architecture. After curation of the genome sequence, many genes in L.
Milind S. Patole +4 more
openaire +3 more sources
Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins [PDF]
mBio, 2017 ABSTRACT Trypanosomatids (order Kinetoplastida), including the human pathogens Trypanosoma cruzi (agent of Chagas disease), Trypanosoma brucei , (African sleeping sickness), and Leishmania (leishmaniasis), affect millions of people and animals globally.
Medeiros, Lia Carolina Soares +8 more
openaire +5 more sources
Aquaculture, Fish and Fisheries, Volume 5, Issue 3, June 2025.ABSTRACT Inland recirculating aquaculture is a thriving food industry providing sustainable and locally sourced high‐quality protein. However, its expansion is accompanied by emerging challenges regarding the spread of pathogens and diseases. Detection and management of pathogens in aquaculture remain underdeveloped compared to other animal farming ...
Jessica Rieder +3 more
wiley +1 more source
G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents [PDF]
Journal of Medicinal Chemistry, 2018 G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses. Here, we present PQS searches on the genomes of T. brucei, L. major, and P. falciparum. We found telomeric sequences and new PQS motifs.
Efres Belmonte-Reche +12 more
openaire +6 more sources
Can Unicellular Organisms Sequester a Germline? The Yeast‐Germline Hypothesis
BioEssays, Volume 47, Issue 6, June 2025.Asymmetrical inheritance of template‐DNA and copy‐DNA strands during mitosis can reduce the number of mutant cells. This requires that cells continuing to divide inherit the “immortal” template‐DNA, while their daughter cells become quiescent and inherit copy‐DNA strands.
Bhavya Sree Vadlamudi, Duur K. Aanen
wiley +1 more source
iMetaOmics, Volume 2, Issue 2, June 2025.Traditional fermented foods in synthetic microbial communities (SynComs). We simulated the production of zha‐chili, a traditional fermented food, in the laboratory, intending to address the following questions: How are SynComs constructed, and what is the effect of inoculation with SynComs on the quality of zha‐chilli? How does inoculation with SynComs
Hongye Shen +7 more
wiley +1 more source
Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies
MedComm, Volume 6, Issue 6, June 2025.Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen +6 more
wiley +1 more source
Nanopore sequencing significantly improves genome assembly of the eukaryotic protozoan parasite Trypanosoma cruzi [PDF]
, 2018 Chagas disease was described by Carlos Chagas, who first identified the parasite Trypanosoma cruzi from a two-year-old girl called Berenice. Many T. cruzi sequencing projects based on short reads have demonstrated that genome assembly and downstream comparative analyses are extremely challenging in this species, given that half of its genome is ...
Diaz-Viraque, Florencia +5 more
openaire +1 more source
Australian Veterinary Journal, Volume 103, Issue 6, Page 322-329, June 2025.The aim of this non‐blinded, randomised, controlled study was to determine the efficacy of toltrazuril for the prevention of oriental theileriosis in calves. Thirty calves were infected with Theileria orientalis Ikeda genotype through the application and retention of infected female bush ticks (Haemaphysalis longicornis). 15 Group 1 calves were treated
SG de Burgh, DL Emery
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.Microglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Yi Wang +13 more
wiley +1 more source