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Informative Regions In Viral Genomes [PDF]
Viruses, far from being just parasites affecting hosts’ fitness, are major players in any microbial ecosystem. In spite of their broad abundance, viruses, in particular bacteriophages, remain largely unknown since only about 20% of sequences obtained from viral community DNA surveys could be annotated by comparison with public databases.
Jaime Leonardo Moreno-Gallego+3 more
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Expansion of Viral Genomes with Viral Protein Genome Linked Copies
Virus protein-linked genome (VPg) proteins are required for replication. VPgs are duplicated in a subset of RNA viruses however their roles are not fully understood and the extent of viral genomes containing VPg copies has not been investigated in detail.
Reid, Warsaba+3 more
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Intracellular sensing of viral genomes and viral evasion [PDF]
AbstractDuring viral infection, virus-derived cytosolic nucleic acids are recognized by host intracellular specific sensors. The efficacy of this recognition system is crucial for triggering innate host defenses, which then stimulate more specific adaptive immune responses against the virus.
Hyun-Cheol Lee+2 more
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Viral component of the human genome [PDF]
Relationships between viruses and their human host are traditionally described from the point of view taking into consideration hosts as victims of viral aggression, which results in infectious diseases. However, these relations are in fact two-sided and involve modifications of both the virus and host genomes.
A. V. Shargunov+4 more
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NCBI Viral Genomes Resource [PDF]
Recent technological innovations have ignited an explosion in virus genome sequencing that promises to fundamentally alter our understanding of viral biology and profoundly impact public health policy. Yet, any potential benefits from the billowing cloud of next generation sequence data hinge upon well implemented reference resources that facilitate ...
Yiming Bao+3 more
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Genomics in Plant Viral Research
Plant viruses constitute a large group of pathogens causing damaging diseases in many agricultural and horticultural crops around the world [...]
Solomon Maina, Brendan Rodoni
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INVERTED REPEATS IN VIRAL GENOMES [PDF]
We investigate 738 complete genomes of viruses to detect the presence of short inverted repeats. The number of inverted repeats found is compared with the prediction obtained for a Bernoullian and for a Markovian control model. We find as a statistical regularity that the number of observed inverted repeats is often greater than the one expected in ...
Rosario N. Mantegna+3 more
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The complexity landscape of viral genomes
Abstract Background Viruses are among the shortest yet highly abundant species that harbor minimal instructions to infect cells, adapt, multiply, and exist. However, with the current substantial availability of viral genome sequences, the scientific repertory lacks a complexity landscape that ...
Jorge Miguel Silva+3 more
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Viral Genomics and Bioinformatics [PDF]
From the recognition by Ivanovski in 1892 that tobacco mosaic disease is caused and transmitted by fine pore filtrates [1], viruses have been isolated, characterized, identified and studied from animals, plants, protists, bacteria and even other viruses [2,3].
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Packing nanomechanics of viral genomes [PDF]
We investigate the osmotic equilibrium between a bulk polyethylene glycol (PEG) solution and DNA tightly packed in a spherical capsid. We base our analysis on the equations of thermodynamic equilibrium in terms of osmotic pressure. The equality between external osmotic pressure of PEG and osmotic pressure of tightly packed DNA gives us the DNA ...
V. A. Parsegian+4 more
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