Results 21 to 30 of about 376,928 (198)

Genomic Analysis of Viral Outbreaks [PDF]

Annual Review of Virology, 2016
Genomic analysis is a powerful tool for understanding viral disease outbreaks. Sequencing of viral samples is now easier and cheaper than ever before and can supplement epidemiological methods by providing nucleotide-level resolution of outbreak-causing pathogens.
Stephen F. Schaffner, Stephen F. Schaffner, Shirlee Wohl, Pardis C. Sabeti, Pardis C. Sabeti   +4 more
openaire   +3 more sources

Sherlock Genomes — viral investigator [PDF]

Nature Reviews Microbiology, 2013
This month's Genome Watch highlights how deep sequencing technologies have vastly reduced the time and prior knowledge needed to generate viral genomes.
Sarah E. Smith, Rachael S. Wash
openaire   +2 more sources

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

Genomics of Avian Viral Infections [PDF]

Genes, 2019
The poultry industry currently accounts for the production of around 118 million metric tons of meat and around 74 million metric tons of eggs annually. As the global population continues to increase, so does our reliance on poultry as a food source. It is therefore of vital importance that we safeguard this valuable resource and make the industry as ...
openaire   +4 more sources

Assembly of viral genomes from metagenomes [PDF]

Frontiers in Microbiology, 2014
Viral infections remain a serious global health issue. Metagenomic approaches are increasingly used in the detection of novel viral pathogens but also to generate complete genomes of uncultivated viruses. In silico identification of complete viral genomes from sequence data would allow rapid phylogenetic characterization of these new viruses.
Saskia L Smits, Saskia L Smits, Rogier eBodewes, Aritz eRuiz-Gonzalez, Aritz eRuiz-Gonzalez, Aritz eRuiz-Gonzalez, Wolfgang eBaumgärtner, Marion P Koopmans, Marion P Koopmans, Albert D. M. E Osterhaus, Albert D. M. E Osterhaus, Anita C Schürch   +11 more
openaire   +5 more sources

On the stability of sequences inserted into viral genomes [PDF]

Virus Evolution, 2019
AbstractViruses are widely used as vectors for heterologous gene expression in cultured cells or natural hosts, and therefore a large number of viruses with exogenous sequences inserted into their genomes have been engineered. Many of these engineered viruses are viable and express heterologous proteins at high levels, but the inserted sequences often ...
Anouk Willemsen, Mark P Zwart
openaire   +6 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Alvira: comparative genomics of viral strains [PDF]

Bioinformatics, 2007
Abstract Motivation: The Alvira tool is a general purpose multiple sequence alignment viewer with a special emphasis on the comparative analysis of viral genomes. This new tool has been devised specifically to address the problem of the simultaneous analysis of a large number of viral strains.
Enault, François, Fremez, Romain, Baranowski, Eric, Faraut, Thomas   +3 more
openaire   +7 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Hamiltonian path analysis of viral genomes [PDF]

Nature Communications, 2018
Cryo-electron microscopy (EM) is undergoing a revolution, enabling the study of viral pathogens in unprecedented detail. The asymmetric EM reconstruction of bacteriophage MS2 at medium resolution (8.7 Å) by Koning et al.1, and the subsequent reconstruction at even higher resolution (3.6 Å) by Dai et al.2 revealed the structures of both the protein ...
Twarock, Reidun, Leonov, German, Stockley, Peter   +2 more
openaire   +5 more sources