Results 31 to 40 of about 2,398,369 (345)

Complete Genome Sequence of Elephant Endotheliotropic Herpesvirus 4, the First Example of a GC-Rich Branch Proboscivirus

mSphere, 2016
A novel group of mammalian DNA viruses called elephant endotheliotropic herpesviruses (EEHVs) belonging to the Proboscivirus genus has been associated with nearly 100 cases of highly lethal acute hemorrhagic disease in young Asian elephants worldwide ...
Paul D. Ling, Simon Y. Long, Angela Fuery, Rong-Sheng Peng, Sarah Y. Heaggans, Xiang Qin, Kim C. Worley, Shannon Dugan, Gary S. Hayward   +8 more
doaj   +1 more source

Genomic epidemiology of SARS-CoV-2 virus with a bioinformatics platform

Universidad Médica Pinareña, 2020
Introduction: viral epidemics have presented a risk to human health since they can turn into pandemics and affect a large part of the population, especially for poor developing countries. In 2020, the worldwide pandemic of COVID-19 is underway.
Sebastian Iglesias-Osores, Percy Omar Tullume-Vergara, Johana Acosta-Quiroz, Johnny Leandro Saavedra-Camacho, Arturo Rafael-Heredia   +4 more
doaj   +2 more sources

Sherlock Genomes — viral investigator [PDF]

Nature Reviews Microbiology, 2013
This month's Genome Watch highlights how deep sequencing technologies have vastly reduced the time and prior knowledge needed to generate viral genomes.
Smith, Sarah E., Wash, Rachael S.
openaire   +2 more sources

The complexity landscape of viral genomes

GigaScience, 2022
Abstract Background Viruses are among the shortest yet highly abundant species that harbor minimal instructions to infect cells, adapt, multiply, and exist. However, with the current substantial availability of viral genome sequences, the scientific repertory lacks a complexity landscape that ...
Jorge Miguel Silva, Diogo Pratas, Tânia Caetano, Sérgio Matos   +3 more
openaire   +3 more sources

Comparison of the Gene Coding Contents and Other Unusual Features of the GC-Rich and AT-Rich Branch Probosciviruses

mSphere, 2016
Nearly 100 cases of lethal acute hemorrhagic disease in young Asian elephants have been reported worldwide. All tested cases contained high levels of elephant endotheliotropic herpesvirus (EEHV) DNA in pathological blood or tissue samples.
Paul D. Ling, Simon Y. Long, Jian-Chao Zong, Sarah Y. Heaggans, Xiang Qin, Gary S. Hayward   +5 more
doaj   +1 more source

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins

Nature Communications, 2019
Programmable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. However, their delivery into target cells can be technically challenging when working with primary cells or in vivo.
P. Mangeot, V. Risson, F. Fusil, A. Marnef, Emilie Laurent, Juliana Blin, V. Mournetas, E. Massouridès, Thibault J. M. Sohier, A. Corbin, Fabien Aubé, Marie Teixeira, C. Pinset, L. Schaeffer, G. Legube, F. Cosset, E. Verhoeyen, T. Ohlmann, Emiliano P. Ricci   +18 more
semanticscholar   +1 more source

Rousette Bat Dendritic Cells Overcome Marburg Virus-Mediated Antiviral Responses by Upregulation of Interferon-Related Genes While Downregulating Proinflammatory Disease Mediators

mSphere, 2019
Dysregulated and maladaptive immune responses are at the forefront of human diseases caused by infection with zoonotic viral hemorrhagic fever viruses. Elucidating mechanisms of how the natural animal reservoirs of these viruses coexist with these agents
Joseph Prescott, Jonathan C. Guito, Jessica R. Spengler, Catherine E. Arnold, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Lisa W. Guerrero, Gustavo F. Palacios, Mariano Sanchez-Lockhart, Cesar G. Albariño, Jonathan S. Towner   +11 more
doaj   +1 more source

Reprogramming human T cell function and specificity with non-viral genome targeting

Nature, 2017
Decades of work have aimed to genetically reprogram T cells for therapeutic purposes1,2 using recombinant viral vectors, which do not target transgenes to specific genomic sites3,4.
Theodore L. Roth, Cristina Puig-Saus, Ruby Yu, Eric Shifrut, J. Carnevale, P. J. Li, J. Hiatt, Justin D. Saco, Paige Krystofinski, Han Li, Victoria R. Tobin, David N. Nguyen, Michael R. Lee, A. Putnam, A. Ferris, Jeff W. Chen, J. Schickel, Laurence Pellerin, D. Carmody, G. Alkorta-Aranburu, D. del Gaudio, Hiroyuki Matsumoto, Montse Morell, Y. Mao, M. Cho, R. Quadros, C. Gurumurthy, Baz Smith, M. Haugwitz, S. Hughes, J. Weissman, Kathrin Schumann, Jonathan H. Esensten, Andy P May, A. Ashworth, Gary M. Kupfer, S. Greeley, R. Bacchetta, E. Meffre, M. Roncarolo, Neil Romberg, K. Herold, A. Ribas, M. Leonetti, A. Marson   +44 more
semanticscholar   +1 more source

Viral Genome Deep Classifier

IEEE Access, 2019
The task of virus classification into subtypes is an important concern in many categorization studies, e.g., in virology or epidemiology. Therefore, the problem of virus subtyping has been a subject of considerable interest in the last decade.
Anna Fabijanska, Szymon Grabowski
doaj   +1 more source

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]

, 2018
G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core   +1 more source