Results 41 to 50 of about 2,398,369 (345)

Influenza A virus RNA polymerase structures provide insights into viral genome replication

Nature, 2019
Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from the transmission of novel zoonotic influenza A viruses to humans1,2.
H. Fan, Alexander P. Walker, L. Carrique, J. Keown, I. Serna Martin, D. Karia, Jane L. Sharps, N. Hengrung, E. Pardon, J. Steyaert, J. Grimes, E. Fodor   +11 more
semanticscholar   +1 more source

Subcellular distribution of the rAAV genome depends on genome structure

Scientific Reports, 2023
Many studies have been conducted on the transduction efficiency of recombinant adeno-associated virus (rAAV) depending on the serotype and genome structure, such as single-stranded (ss) and self-complementary (sc).
Nuri Oh, Naresh H. Tarte
doaj   +1 more source

Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably? [PDF]

, 2004
During virus assembly, all retroviruses specifically encapsidate two copies of full-length viral genomic RNA in the form of a non-covalently linked RNA dimer.
Liang, Chen, Russell, Rodney S, Wainberg, Mark A   +2 more
core   +3 more sources

Molecular characterisation of integrated sequences of Banana streak virus in the banana plant genome [PDF]

, 2009
The genome of banana (Musa sp.) harbours multiple integrations of several species of Banana streak virus (BSV), certainly resulting from illegitimate recombination between host and viral DNA. Surprisingly, this pararetrovirus does not require integration
Baurens, Franc-Christophe, Chabannes, Matthieu, Gayral, Philippe, Guidolin, Olivier, Iskra Caruana, Marie-Line, Laboureau, Nathalie, Sidibé-Bocs, Stéphanie   +6 more
core   +2 more sources

Transcriptomics Reveal Antiviral Gene Induction in the Egyptian Rousette Bat Is Antagonized In Vitro by Marburg Virus Infection

Viruses, 2018
The Egyptian rousette bat (ERB) is the only known Marburg virus (MARV) reservoir host. ERBs develop a productive MARV infection with low viremia and shedding but no overt disease, suggesting this virus is efficiently controlled by ERB antiviral responses.
Catherine E. Arnold, Jonathan C. Guito, Louis A. Altamura, Sean P. Lovett, Elyse R. Nagle, Gustavo F. Palacios, Mariano Sanchez-Lockhart, Jonathan S. Towner   +7 more
doaj   +1 more source

Allosteric HIV-1 integrase inhibitors lead to premature degradation of the viral RNA genome and integrase in target cells [PDF]

, 2017
Recent evidence indicates that inhibition of HIV-1 integrase (IN) binding to the viral RNA genome by allosteric integrase inhibitors (ALLINIs) or through mutations within IN yields aberrant particles in which the viral ribonucleoprotein complexes (vRNPs)
Elliott, Jennifer, Errando, Manel, Koneru, Pratibha C, Kutluay, Sebla B, Kvaratskhelia, Mamuka, Lawson, Dana Q, Madison, Michaela K, Ozanturk, Ayse Naz, Townsend, Dana   +8 more
core   +2 more sources

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

Nature Biotechnology, 2016
The combination of Cas9, guide RNA and repair template DNA can induce precise gene editing and the correction of genetic diseases in adult mammals. However, clinical implementation of this technology requires safe and effective delivery of all of these ...
Hao Yin, Chun‐Qing Song, J. R. Dorkin, L. Zhu, Yingxiang Li, Qiongqiong Wu, Angela I. Park, Jung H. Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, M. Bolukbasi, Stephen Walsh, R. Bogorad, G. Gao, Z. Weng, Yizhou Dong, V. Koteliansky, S. Wolfe, R. Langer, Wen Xue, Daniel G. Anderson   +21 more
semanticscholar   +1 more source

Telomeres and Viruses: Common Themes of Genome Maintenance

Frontiers in Oncology, 2012
Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging. Some viruses provoke genetic instability by subverting the host’s control of genome maintenance.
Zhong eDeng, Zhuo eWang, Paul M Lieberman   +2 more
doaj   +1 more source

A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. [PDF]

, 2014
UnlabelledPairing high-throughput sequencing technologies with high-throughput mutagenesis enables genome-wide investigations of pathogenic organisms. Knowledge of the specific functions of protein domains encoded by the genome of the hepatitis C virus ...
Arumugaswami, Vaithilingaraja, Chen, Shu-Hwa, Chen, Zugen, Chu, Virginia, Lin, Chung-Yen, Lo, Hung-Hao, Olson, C Anders, Qi, Hangfei, Remenyi, Roland, Stokelman, Tamar, Su, Sheng-Yao, Sun, Ren, Truong, Shawna, Wu, Nicholas C, Wu, Ting-Ting   +14 more
core   +2 more sources

Temporal Viral Genome-Protein Interactions Define Distinct Stages of Productive Herpesviral Infection

mBio, 2018
Herpesviruses utilize multiple mechanisms to redirect host proteins for use in viral processes and to avoid recognition and repression by the host. To investigate dynamic interactions between herpes simplex virus type 1 (HSV-1) DNA and viral and host ...
Jill A. Dembowski, N. DeLuca
semanticscholar   +1 more source