Results 51 to 60 of about 776,538 (310)

A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. [PDF]

, 2014
UnlabelledPairing high-throughput sequencing technologies with high-throughput mutagenesis enables genome-wide investigations of pathogenic organisms. Knowledge of the specific functions of protein domains encoded by the genome of the hepatitis C virus ...
Arumugaswami, Vaithilingaraja, Chen, Shu-Hwa, Chen, Zugen, Chu, Virginia, Lin, Chung-Yen, Lo, Hung-Hao, Olson, C Anders, Qi, Hangfei, Remenyi, Roland, Stokelman, Tamar, Su, Sheng-Yao, Sun, Ren, Truong, Shawna, Wu, Nicholas C, Wu, Ting-Ting   +14 more
core   +2 more sources

Alvira: comparative genomics of viral strains [PDF]

Bioinformatics, 2007
Abstract Motivation: The Alvira tool is a general purpose multiple sequence alignment viewer with a special emphasis on the comparative analysis of viral genomes. This new tool has been devised specifically to address the problem of the simultaneous analysis of a large number of viral strains.
Enault, François, Fremez, Romain, Baranowski, Eric, Faraut, Thomas   +3 more
openaire   +6 more sources

Active Ebola Virus Replication and Heterogeneous Evolutionary Rates in EVD Survivors

Cell Reports, 2018
Summary: Following cessation of continuous Ebola virus (EBOV) transmission within Western Africa, sporadic EBOV disease (EVD) cases continued to re-emerge beyond the viral incubation period.
Shannon L.M. Whitmer, Jason T. Ladner, Michael R. Wiley, Ketan Patel, Gytis Dudas, Andrew Rambaut, Foday Sahr, Karla Prieto, Samuel S. Shepard, Ellie Carmody, Barbara Knust, Dhamari Naidoo, Gibrilla Deen, Pierre Formenty, Stuart T. Nichol, Gustavo Palacios, Ute Ströher   +16 more
doaj   +1 more source

Human Cytomegalovirus Genomes Survive Mitosis via the IE19 Chromatin-Tethering Domain

mBio, 2020
The genomes of DNA tumor viruses regain nuclear localization after nuclear envelope breakdown during mitosis through the action of a viral protein with a chromatin-tethering domain (CTD).
Shelby M. Lyon, Kristen D. Yetming, Christina Paulus, Michael Nevels, Robert F. Kalejta   +4 more
doaj   +1 more source

Chemistry and Bioinformatics Considerations in Using Next-Generation Sequencing Technologies to Inferring HIV Proviral DNA Genome-Intactness

Viruses, 2021
HIV persists via integration of the viral DNA into the human genome. The HIV DNA pool within an infected individual is a complex population that comprises both intact and defective viral genomes, each with a distinct integration site, in addition to a ...
Guinevere Q. Lee
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Efficient isolation on Vero.DogSLAMtag cells and full genome characterization of Dolphin Morbillivirus (DMV) by next generation sequencing [PDF]

, 2018
The Dolphin Morbillivirus (DMV) genome from the frst Mediterranean epidemic (1990-\u201992) is the only cetacean Morbillivirus that has been completely sequenced.
Acutis, Pier Luigi, Biolatti, Cristina, Caruso, Claudio, Casalone, Cristina, Cerutti, Francesco, Giorda, Federica, Grattarola, Carla, Masoero, Loretta, Mazzariol, Sandro, Mignone, Walter, Modesto, Paola, Pautasso, Alessandra, Peletto, Simone   +12 more
core   +2 more sources

Viral component of the human genome [PDF]

Molecular Biology, 2017
Relationships between viruses and their human host are traditionally described from the point of view taking into consideration hosts as victims of viral aggression, which results in infectious diseases. However, these relations are in fact two-sided and involve modifications of both the virus and host genomes.
Blinov, V. M., Zverev, V. V., Krasnov, G. S., Filatov, F. P., Shargunov, A. V.   +4 more
openaire   +3 more sources

Dengue Virus Genome Uncoating Requires Ubiquitination

mBio, 2016
The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile ...
Laura A. Byk, Néstor G. Iglesias, Federico A. De Maio, Leopoldo G. Gebhard, Mario Rossi, Andrea V. Gamarnik   +5 more
doaj   +1 more source

ARHGAP1 Transported with Influenza Viral Genome Ensures Integrity of Viral Particle Surface through Efficient Budozone Formation

mBio, 2022
Influenza viral particles are assembled at the plasma membrane concomitantly with Rab11a-mediated endocytic transport of viral ribonucleoprotein complexes (vRNPs).
Takahiro Kuroki, Tomohisa Hatta, Tohru Natsume, Nobuaki Sakai, Akira Yagi, Kohsuke Kato, Kyosuke Nagata, Atsushi Kawaguchi   +7 more
doaj   +1 more source