Results 41 to 50 of about 669,401 (295)

Main insights of genome wide association studies into HCV-related HCC

Egyptian Liver Journal, 2020
Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-mortality globally. Hepatocarcinogenesis is a complex multifactorial process.
Inas Maged Moaz, Ayat Rushdy Abdallah, Marwa Fekry Yousef, Sameera Ezzat   +3 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Single-Locus and Multi-Locus Genome-Wide Association Studies for Intramuscular Fat in Duroc Pigs

Frontiers in Genetics, 2019
Intramuscular fat (IMF) is an important quantitative trait of meat, which affects the associated sensory properties and nutritional value of pork. To gain a better understanding of the genetic determinants of IMF, we used a composite strategy, including ...
Rongrong Ding, Ming Yang, Jianping Quan, Shaoyun Li, Zhanwei Zhuang, Shenping Zhou, Enqin Zheng, Linjun Hong, Zicong Li, Gengyuan Cai, Gengyuan Cai, Wen Huang, Zhenfang Wu, Zhenfang Wu, Jie Yang   +14 more
doaj   +1 more source

Rapid scoring of genes in microbial pan-genome-wide association studies with Scoary

Genome Biology, 2016
Genome-wide association studies (GWAS) have become indispensable in human medicine and genomics, but very few have been carried out on bacteria. Here we introduce Scoary, an ultra-fast, easy-to-use, and widely applicable software tool that scores the ...
O. Brynildsrud, J. Bohlin, Lonneke Scheffer, Vegard Eldholm   +3 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Identification of novel drug targets for multiple sclerosis by integrating plasma genetics and proteomes

Experimental Gerontology
Background: Genome-wide association studies (GWAS) have revealed numerous loci associated with multiple sclerosis (MS). However, the challenge lies in deciphering the mechanisms by which these loci influence the target traits.
Yi Liu, Qian Wang, Yuhui Zhao, Liu Liu, Jingxi Hu, Yao Qiao, Jinyi Chen, Chao Qin   +7 more
doaj   +1 more source

The Human Microbiome and the Missing Heritability Problem

Frontiers in Genetics, 2017
The “missing heritability” problem states that genetic variants in Genome-Wide Association Studies (GWAS) cannot completely explain the heritability of complex traits.
Santiago Sandoval-Motta, Maximino Aldana, Maximino Aldana, Esperanza Martínez-Romero, Alejandro Frank, Alejandro Frank, Alejandro Frank   +6 more
doaj   +1 more source

Gene-centric characteristics of genome-wide association studies. [PDF]

PLoS ONE, 2007
BACKGROUND: The high-throughput genotyping chips have contributed greatly to genome-wide association (GWA) studies to identify novel disease susceptibility single nucleotide polymorphisms (SNPs).
Changzheng Dong, Ziliang Qian, Peilin Jia, Ying Wang, Wei Huang, Yixue Li   +5 more
doaj   +1 more source

Identifying and Exploring the Candidate Susceptibility Genes of Cirrhosis Using the Multi-Tissue Transcriptome-Wide Association Study

Frontiers in Genetics, 2022
Objective: We identify and explore the candidate susceptibility genes for cirrhosis and their underlying biological mechanism.Methods: We downloaded the genome-wide association studies summary data of 901 cirrhosis cases and 451,363 controls and ...
Xiao-Bo Zhu, Yu-Qing Hou, Xiang-Yu Ye, Yi-Xin Zou, Xue-Shan Xia, Sheng Yang, Peng Huang, Rong-Bin Yu   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source