Genome-wide association studies in asthma [PDF]
, 2016 Asthma is a complex respiratory disease, with both genetic and environmental factors contributing to disease susceptibility. Genome-wide association studies (GWAS) have now identified novel risk alleles and loci associated with asthma diagnosis and more ...
Bochkov +49 more
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Reporting and Interpretation in Genome-Wide Association Studies [PDF]
, 2007 In the context of genome-wide association studies we critique a number of methods that have been suggested for flagging associations for further investigation.
Wakefield, Jon
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SNPpy--database management for SNP data from genome wide association studies. [PDF]
PLoS ONE, 2011 We describe SNPpy, a hybrid script database system using the Python SQLAlchemy library coupled with the PostgreSQL database to manage genotype data from Genome-Wide Association Studies (GWAS). This system makes it possible to merge study data with HapMap
Faheem Mitha +5 more
doaj +1 more source
A fast algorithm for detecting gene-gene interactions in genome-wide association studies [PDF]
, 2014 With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches.
Li, Jiahan +3 more
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Simulating variance heterogeneity in quantitative genome wide association studies
BMC Bioinformatics, 2018 Background Analyzing Variance heterogeneity in genome wide association studies (vGWAS) is an emerging approach for detecting genetic loci involved in gene-gene and gene-environment interactions.
Ahmad Al Kawam +4 more
doaj +1 more source
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances [PDF]
, 2013 Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption we performed a population based genome-wide association study ...
Alexei I. Zhurov +84 more
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Status and prospects of genome‐wide association studies in plants
The Plant Genome, 2021 Genome‐wide association studies (GWAS) have developed into a powerful and ubiquitous tool for the investigation of complex traits. In large part, this was fueled by advances in genomic technology, enabling us to examine genome‐wide genetic variants ...
Laura Tibbs Cortes +2 more
doaj +1 more source
Replicability analysis for genome-wide association studies
, 2014 The paramount importance of replicating associations is well recognized in the genome-wide associaton (GWA) research community, yet methods for assessing replicability of associations are scarce. Published GWA studies often combine separately the results
Heller, Ruth, Yekutieli, Daniel
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Genetics of common polygenic ischaemic stroke: current understanding and future challenges. [PDF]
, 2011 Stroke is the third commonest cause of death and the major cause of adult neurological disability worldwide. While much is known about conventional risk factors such as hypertension, diabetes and incidence of smoking, these environmental factors only ...
Bevan, S, Markus, HS
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Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity [PDF]
, 2020 There has been extensive discussion of the Replication Crisis in many fields, including genome-wide association studies
Cheng, Riyan +7 more
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