Results 61 to 70 of about 833,983 (263)

Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults [PDF]

Endocrinology and Metabolism, 2020
Background As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score (TBS).
Sung Hye Kong, Ji Won Yoon, Jung Hee Kim, JooYong Park, Jiyeob Choi, Ji Hyun Lee, A Ram Hong, Nam H. Cho, Chan Soo Shin   +8 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
AIMS: To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association
Angelakopoulou, A, Berry, DJ, Casas, JP, Caulfield, M, Cooper, J, de Faire, U, Deanfield, J, Drenos, F, Fowkes, FG, Gigante, B, Hardy, R, Hingorani, AD, Humphries, SE, Hypponen, E, Ireland, H, Jefferis, BJ, Kivimaki, M, Kuh, D, Kumari, M, Lathrop, M, Laxton, RC, Leander, K, Maniatis, N, Marmot, M, Morris, RW, Motterle, A, Munroe, PB, Palmen, J, Power, C, Price, J, Samani, N, Shah, S, Shah, T, Simpson, IA, Smeeth, L, Sofat, R, Talmud, PJ, Thomson, A, Tzoulaki, I, Verzilli, C, Wallace, C, Whincup, PH, Whittaker, JC, Wong, A, Ye, S   +44 more
core   +4 more sources

Genome-wide association studies in cancer [PDF]

Human Molecular Genetics, 2008
Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that ...
Douglas F, Easton, Rosalind A, Eeles
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Role of Family-Based Designs in Genome-Wide Association Studies [PDF]

, 2009
Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs.
Laird, Nan M., Lange, Christoph
core   +1 more source

Single-Locus and Multi-Locus Genome-Wide Association Studies for Intramuscular Fat in Duroc Pigs

Frontiers in Genetics, 2019
Intramuscular fat (IMF) is an important quantitative trait of meat, which affects the associated sensory properties and nutritional value of pork. To gain a better understanding of the genetic determinants of IMF, we used a composite strategy, including ...
Rongrong Ding, Ming Yang, Jianping Quan, Shaoyun Li, Zhanwei Zhuang, Shenping Zhou, Enqin Zheng, Linjun Hong, Zicong Li, Gengyuan Cai, Gengyuan Cai, Wen Huang, Zhenfang Wu, Zhenfang Wu, Jie Yang   +14 more
doaj   +1 more source

Main insights of genome wide association studies into HCV-related HCC

Egyptian Liver Journal, 2020
Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-mortality globally. Hepatocarcinogenesis is a complex multifactorial process.
Inas Maged Moaz, Ayat Rushdy Abdallah, Marwa Fekry Yousef, Sameera Ezzat   +3 more
doaj   +1 more source

Genome-wide gene-based association study [PDF]

BMC Proceedings, 2009
Genome-wide association studies, which analyzes hundreds of thousands of single-nucleotide polymorphisms to identify disease susceptibility genes, are challenging because the work involves intensive computation and complex modeling. We propose a two-stage genome-wide association scanning procedure, consisting of a single-locus association scan for the ...
Yang, Hsin-Chou, Liang, Yu-Jen, Chung, Chia-Min, Chen, Jia-Wei, Pan, Wen-Harn   +4 more
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source