Results 61 to 70 of about 24,640 (259)

Sequencing and assembling bear genomes: the bare necessities

Frontiers in Zoology, 2022
AbstractUnique genetic adaptations are present in bears of every species across the world. From (nearly) shutting down important organs during hibernation to preventing harm from lifestyles that could easily cause metabolic diseases in humans, bears may hold the answer to various human ailments.
Courtney Willey, Ron Korstanje
openaire   +4 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. [PDF]

, 2014
Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on ...
Studholme, David J., Holden, Mathew TG, Chen, Swaine L., Holden, Matthew T. G., Baybayan, Primo, Peak, Ian, Nandi, Tannistha, Boddey, Justin A., Holden, Matthew, Guo, Yan, Sim, Bernice, Didelot, Xavier, Smither, Sophie, Beacham, Ifor, Holden, Matthew TG, Nelson, Michelle, Ong, Catherine, Michell, Stephen, Aw, Lay Tin, Chen, Swaine L, Titball, Richard, Hoon, Chua Hui, Boddey, Justin A, Parkhill, Julian, Mehershahi, Kurosh, Tan, Patrick, How, Lee Chee, Sarkar-Tyson, Mitali, Wang, Susana, Essex-Lopresti, Angela, Studholme, David J, Harting, John, Holden, Matthew; id_orcid   +32 more
core   +1 more source

A deep dive into genome assemblies of non-vertebrate animals

Peer Community Journal, 2022
Non-vertebrate species represent about 95% of known metazoan (animal) diversity. They remain to this day relatively unexplored genetically, but understanding their genome structure and function is pivotal for expanding our current knowledge of evolution,
Guiglielmoni, Nadège, Rivera-Vicéns, Ramón, Koszul, Romain, Flot, Jean-François   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The complexity of Rhipicephalus (Boophilus) microplus genome characterised through detailed analysis of two BAC clones [PDF]

, 2011
Background Rhipicephalus (Boophilus) microplus (Rmi) a major cattle ectoparasite and tick borne disease vector, impacts on animal welfare and industry productivity.
Peterson, D., Morgan Jess A T, Moolhuijzen, Paula M., Moolhuijzen, P.M., Dowd, S.E, Peterson, Daniel G., Bellgard, Matthew I., Bellgard Matthew I, Dowd Scot E, Bellgard, M.I., Appels, Rudi, Peterson Daniel G, Daniel G Peterson, Manuel Valle, Guerrero, F., Lew-Tabor, Ala E., Paula M Moolhuijzen, Valle, M.R., Appels Rudi, Moolhuijzen Paula M, Felix D Guerrero, Lew-Tabor, A.E., Lew-Tabor Ala E, Manuel Rodriguez Valle, Guerrero, F.D., Matthew I Bellgard, Lew-Tabor, A., Valle, Manuel Rodriguez, Guerrero Felix D, Moolhuijzen, Paula, Dowd, Scot E., Morgan, J.A.T., Dowd, S., Morgan, J., Valle, M., Bellgard, M., Scot E Dowd, Valle Manuel, Jess A T Morgan, Peterson, D.G., Appels, R., Rudi Appels, Ala E Lew-Tabor, Morgan, Jess A.T., Guerrero, Felix D., Department of Primary Industries, Queensland   +45 more
core   +2 more sources

Long-read sequence assembly of the gorilla genome [PDF]

Science, 2016
Improving on the gorilla genome Access to complete, high-quality genomes of nonhuman primates will also help us understand human biology. Gordon et al. used long-read sequencing technology to improve genome data on our close relative the gorilla.
Gordon, David, Huddleston, John, Chaisson, Mark JP, Hill, Christopher M, Kronenberg, Zev N, Munson, Katherine M, Malig, Maika, Raja, Archana, Fiddes, Ian, Hillier, LaDeana W, Dunn, Christopher, Baker, Carl, Armstrong, Joel, Diekhans, Mark, Paten, Benedict, Shendure, Jay, Wilson, Richard K, Haussler, David, Chin, Chen-Shan, Eichler, Evan E   +19 more
openaire   +4 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Challenges, Solutions, and Quality Metrics of Personal Genome Assembly in Advancing Precision Medicine

Pharmaceutics, 2016
Even though each of us shares more than 99% of the DNA sequences in our genome, there are millions of sequence codes or structure in small regions that differ between individuals, giving us different characteristics of appearance or responsiveness to ...
Wenming Xiao, Leihong Wu, Gokhan Yavas, Vahan Simonyan, Baitang Ning, Huixiao Hong   +5 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source