Results 91 to 100 of about 23,710,291 (301)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Genomic homogeneity in fibrolamellar carcinomas [PDF]

, 2001
Background-Fibrolamellar carcinoma (FLC) is a variant of hepatocellular carcinoma (HCC) with distinctive clinical and histological features. To date there have been few studies on the genotypic aspects of FLC and no previous attempts have been made to ...
Davidson, BR, Lemoine, NR, Sirivatanauksorn, V, Sirivatanauksorn, Y, Williamson, RCN   +4 more
core  

Genomic Diversity among Beijing and non-Beijing Mycobacterium tuberculosis Isolates from Myanmar [PDF]

, 2008
Background: The Beijing family of Mycobacterium tuberculosis is dominant in countries in East Asia. Genomic polymorphisms are a source of diversity within the M. tuberculosis genome and may account for the variation of virulence among M.
Hinds Jason, Grewal, HM, Butcher, PD, Stavrum Ruth, Stavrum, R, Bø, TH, Ruth Stavrum, Valvatne, H, Trond H Bø, Jonassen, I, Philip D Butcher, Valvatne Håvard, Bø Trond H., Hinds, J, Butcher Philip D., Jonassen Inge, Inge Jonassen, Jason Hinds, Håvard Valvatne, Harleen M S Grewal, Grewal Harleen M. S.   +20 more
core   +1 more source

Functional Genomics and Comparative Genomics Analysis in Plants

Current Issues in Molecular Biology
The study of plant genomics has significantly deepened our understanding of plant evolution and adaptation from a microscopic perspective [...]
Yueqi Lu, Quan Zou
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Roles of pharmacists in cancer genomic medicine.

, 2020
The development of cancer genomic medicine has been embraced as an important new policy issue in “The 3rd Basic Plan to Promote Cancer Control Programs” formulated by the Japanese government.
675, 10324641, TERADA, Tomohiro, 寺田, 智祐   +3 more
core   +1 more source

Estimating genomic breeding values and detecting QTL using univariate and bivariate models [PDF]

, 2011
Background Genomic selection is particularly beneficial for difficult or expensive to measure traits. Since multi-trait selection is an important tool to deal with such cases, an important question is what the added value is of multi-trait genomic ...
Calus, M.P.L., Han A Mulder, Roel F Veerkamp, Veerkamp, R.F., Mulder, H.A., Mario PL Calus   +5 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Genomic Selective Constraints in Murid Noncoding DNA [PDF]

, 2006
Recent work has suggested that there are many more selectively constrained, functional noncoding than coding sites in mammalian genomes. However, little is known about how selective constraint varies amongst different classes of noncoding DNA.
Peter D Keightley, Daniel J Gaffney, Gaffney Daniel J, Keightley, Peter, Keightley Peter D, Gaffney, Daniel   +5 more
core   +2 more sources

Sibutramine high-doses effects in cafeteria diet-induced obese rats

Scientific Reports
Obesity, defined as excessive fat accumulation that impairs health, is a global challenge with high mortality rates. Sibutramine, a centrally acting anorectic, was widely used in obesity treatment due to its effects on appetite control and weight loss ...
Filipe M. Ribeiro, Henny K. Lima, Camila F. A. Ribeiro, Osmar N. Silva, Guilherme Mendonça, Nathalia Cavichiolli de Oliveira, Rinaldo W. Pereira, Alinne P. de Castro, Octávio L. Franco   +8 more
doaj   +1 more source