Results 81 to 90 of about 23,710,291 (301)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

B mu G@Sbase-a microbial gene expression and comparative genomic database [PDF]

, 2011
The reducing cost of high-throughput functional genomic technologies is creating a deluge of high volume, complex data, placing the burden on bioinformatics resources and tool development. The Bacterial Microarray Group at St George's (BμG@S) has been at
Butcher, PD, P. D. Butcher, Tyler, RH, Hinds, Jason, Butcher, P D, Wren, Brendan W, LSHTM, Stoker, NG, N. G. Stoker, L. A. Brooks, Waldron, DE, Brooks, Lucy A, Butcher, Philip D, Wren, BW, M. Withers, Witney, AA, Stoker, N G, Witney, A A, Waldron, Denise E, Witney, Adam A, Wren, B W, Brooks, L A, Waldron, D E, B. W. Wren, Stoker, Neil G, A. A. Witney, Hinds, J, Withers, M, Tyler, Richard H, R. H. Tyler, Tyler, R H, London, J. Hinds, Withers, Michael, D. E. Waldron, Brooks, LA   +35 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

PolyTB: a genomic variation map for Mycobacterium tuberculosis [PDF]

, 2014
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second major cause of death from an infectious disease worldwide. Recent advances in DNA sequencing are leading to the ability to generate whole genome information in clinical isolates ...
Gagneux, S., Perdigão, João, McNerney, R., Glynn, Judith R., McNerney, Ruth, Preston, M., Perdigao, J., Gagneux, Sebastien, Viveiros, M., Glynn, Judith R, Guerra-Assunção, José Afonso, Glynn, J., Parkhill, J., Harris, D., Clark, T., Coll, Francesc, Viveiros, Miguel, Hill-Cawthorne, G., Hill-Cawthorn, Grant, Pain, A., Pain, Arnab, Clark, Taane G., Portugal, I., Parkhill, Julian, Preston, Mark, Drobniewski, Francis, Drobniewski, F., Portugal, Isabel, Martin, Nigel, Guerra-Assuncao, J., Harris, David, Coll, F., Clark, Taane G   +32 more
core   +1 more source

Spatial-temporal distribution of genotyped tuberculosis cases in a county with active transmission

BMC Infectious Diseases, 2017
Background Harris County, Texas is the third most populous county in the United States and consistently has tuberculosis rates above the national average.
Saroochi Agarwal, Duc T. Nguyen, Larry D. Teeter, Edward A. Graviss   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Integrative Bayesian Network Analysis of Genomic Data

, 2014
Rapid development of genome-wide profiling technologies has made it possible to conduct integrative analysis on genomic data from multiple platforms. In this study, we develop a novel integrative Bayesian network approach to investigate the relationships
Francesco C. Stingo, Yang Ni, Veerabhadran Baladandayuthapani   +2 more
core   +1 more source

On the weight of indels in genomic distances [PDF]

, 2011
Dias Vieira Braga M, Machado R, Ribeiro LC, Stoye J. On the weight of indels in genomic distances. BMC Bioinformatics. 2011;12(Suppl 9: RECOMB-CG 2011): S13.Background: Classical approaches to compute the genomic distance are usually limited to genomes ...
Machado, Raphael, Stoye, Jens ; https://orcid.org/, Dias Vieira Braga, Marília, Ribeiro, Leonardo C.   +3 more
core   +1 more source

Genomic Analysis of Laccaria Genomes at High Altitude

Journal of Fungi
The Qinghai–Tibet Plateau (QTP) harbors extreme environmental conditions (e.g., low temperature, intense UV radiation, and hypoxia), presenting unique challenges for biological adaptation. However, the genetic mechanisms underlying the adaptation of macrofungi to high-altitude environments on the QTP remain poorly understood.
Yu Bao, Ye Mu, Jinghuan Hu, Mengchao Chen, Jing Xing   +4 more
openaire   +2 more sources

Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms

Disease Models & Mechanisms, 2018
In the past, amyotrophic lateral sclerosis (ALS) has been considered a ‘neurocentric’ disease; however, new evidence suggests that it should instead be looked at from a ‘multisystemic’ or ‘non-neurocentric’ point of view.
Orietta Pansarasa, Matteo Bordoni, Lorenzo Drufuca, Luca Diamanti, Daisy Sproviero, Rosa Trotti, Stefano Bernuzzi, Sabrina La Salvia, Stella Gagliardi, Mauro Ceroni, Cristina Cereda   +10 more
doaj   +1 more source