Results 71 to 80 of about 23,710,291 (301)

Isoform analysis of heterozygous putative splicing variants at the allele level using nanopore long-read sequencing

Scientific Reports
One of the challenges in clinical genetics for rare diseases and personalized medicine is evaluating isoform alterations arising from heterozygous putative splicing variants at the allele level.
Kokoro Ozaki, Takashi Irioka, Shohei Noma, Akira Machida, Moe Fukunaga, Tatsuro Murano, Chitose Takahashi, Michihira Tagami, Tsugumi Kawashima, Tomoko Hirata, Yuki Yasuoka, Hiroya Kuwahara, Toshiyuki Araki, Ken Yagi, Hidehiro Mizusawa, Kinya Ishikawa, Yasushi Okazaki, Takanori Yokota   +17 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Antimicrobial resistance and virulence determinants in European Salmonella genomic island 1-positive Salmonella enterica isolates from different origins. [PDF]

, 2011
Salmonella genomic island 1 (SGI1) contains a multidrug resistance region conferring the ampicillin-chloramphenicol-streptomycin-sulfamethoxazole-tetracycline resistance phenotype encoded by bla(PSE-1), floR, aadA2, sul1, and tet(G).
Hauser, E., Dep Infectieziekten Immunologie, Advances in Veterinary Medicine, Beutlich, Janine, Rodicio, M. R., Schroeter, A., Threlfall, J., Med-Vet-Net WP21 Project Group, Janine Beutlich, Bernd Appel, Malorny, B., Trelfall, J., Andreas Schroeter, Malorny, Burkhard, Thelfall, J., Helmuth, R., Jahn, S., Burkhard Malorny, Elisabeth Hauser, Reiner Helmuth, Stephan Hühn, Dik Mevius, Beatriz Guerra, Mevius, D.J., Rodicio, M.R., Maria Rosario Rodicio, Jahn, Silke, John Threlfall, Appel, B., Rodicio Rodicio, María del Rosario, Silke Jahn, Hühn, S., Mevius, D., Beutlich, J., Rosario Rodicio, M., Guerra, B.   +35 more
core   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach [PDF]

, 2009
Diaz NN, Krause L, Goesmann A, Niehaus K, Nattkemper TW. TACOA - Taxonomic classification of environmental genomic fragments using a kernelized nearest neighbor approach. BMC Bioinformatics.
Nattkemper, Tim Wilhelm ; https://orcid.org/, Nattkemper Tim W, Naryttza N Diaz, Lutz Krause, Krause, Lutz, Niehaus Karsten, Diaz Naryttza N, Goesmann, Alexander ; https://orcid.org/, Goesmann Alexander, Niehaus, Karsten, Tim W Nattkemper, Goesmann, Alexander, Karsten Niehaus, Diaz, Naryttza N., Nattkemper, Tim W., Krause Lutz, Alexander Goesmann   +16 more
core   +1 more source

Integrated molecular characterization of adult soft tissue sarcoma for therapeutic targets

BMC Medical Genetics, 2018
Background Several studies have investigated the molecular drivers and therapeutic targets in adult soft tissue sarcomas. However, such studies are limited by the genomic heterogeneity and rarity of sarcomas, particularly in those with complex and ...
Jihyun Kim, June Hyuk Kim, Hyun Guy Kang, Seog Yun Park, Jung Yeon Yu, Eun Young Lee, Sung Eun Oh, Young Ho Kim, Tak Yun, Charny Park, Soo Young Cho, Hye Jin You   +11 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Estrogen Receptor α Is Crucial in Zearalenone-Induced Invasion and Migration of Prostate Cancer Cells

Toxins, 2018
Zearalenone (ZEA), a mycotoxin produced in the genus Fusarium, binds to estrogen receptors (ER) and is therefore regarded as an endocrine disruptor. ZEA has also been found to modulate the proliferation and apoptosis of prostate cancer cells in a dose ...
Karolina Kowalska, Dominika Ewa Habrowska-Górczyńska, Kinga Anna Urbanek, Kamila Domińska, Agnieszka Wanda Piastowska-Ciesielska   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

MethylToSNP: identifying SNPs in Illumina DNA methylation array data

Epigenetics & Chromatin, 2019
Background Current array-based methods for the measurement of DNA methylation rely on the process of sodium bisulfite conversion to differentiate between methylated and unmethylated cytosine bases in DNA.
Brenna A. LaBarre, Alexander Goncearenco, Hanna M. Petrykowska, Weerachai Jaratlerdsiri, M. S. Riana Bornman, Vanessa M. Hayes, Laura Elnitski   +6 more
doaj   +1 more source