Results 181 to 190 of about 2,120,585 (276)

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Integrated genomic analysis and CRISPRi implicates <i>EGFR</i> in Alzheimer's disease risk. [PDF]

NPJ Dement
Leung YY, Kuksa PP, Carter L, Cifello J, Greenfest-Allen E, Valladares O, Boateng L, Laub S, Tulina N, Moura S, Ramirez A, Celis K, Jin F, Feng R, Wang G, De Jager P, Vance JM, Wang L, Grant SFA, Schellenberg GD, Chesi A, Wang LS.   +21 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Comparative Genomic Analysis of <i>Pseudomonas aeruginosa</i> Isolates from Community-Acquired and Hospital-Acquired Pneumonia. [PDF]

Infect Drug Resist
Yang F, Chai S, Yan L, He Y, Ma X, Shen L, Gao S, Guo Y, Zhang Z, Ni W, Bao J, Gao Z.   +11 more
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Comparative Genomic Analysis and Functional Identification of CER1 and CER3 Homologs in Rice Wax Synthesis. [PDF]

Biology (Basel)
Youssif NEE, Yang B, Huang H, Amar MH, Ezzat M, Belal M, Zaghlool SAM, Zhao H, Fu D, Lü S.   +9 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor. [PDF]

Toxicol Sci
Shahriar S, Patel TD, Nakka M, Grimm SL, Coarfa C, Gorelick DA.   +5 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Editorial: Expert opinions in genomic analysis. [PDF]

Front Bioinform
Setubal JC, Paccanaro A.
europepmc   +1 more source