Results 51 to 60 of about 2,120,585 (276)

Characteristics of the gut microbiome profile in obese patients with colorectal cancer

JGH Open, 2021
Background and Aim Obesity affects the gut microbiome, which in turn increases the risk for colorectal cancer. Several studies have shown the mechanisms by which some bacteria may influence the development of colorectal cancer; however, gut microbiome ...
Masakuni Shoji, Yu Sasaki, Yasuhiko Abe, Shoichi Nishise, Takao Yaoita, Makoto Yagi, Naoko Mizumoto, Takashi Kon, Yusuke Onozato, Takayuki Sakai, Matsuki Umehara, Minami Ito, Ayumi Koseki, Ryoko Murakami, Yuki Miyano, Hidenori Sato, Yoshiyuki Ueno   +16 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development

Nature Communications, 2018
Cytokinin fulfills its diverse roles in planta through a series of transcriptional responses. We identify the in vivo DNA binding site profiles for three genetically redundant type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs): ARR1, ARR10, and ARR12.
Mingtang Xie, Hongyu Chen, Ling Huang, Ryan C. O’Neil, Maxim N. Shokhirev, Joseph R. Ecker   +5 more
doaj   +1 more source

MISSEL: a method to identify a large number of small species-specific genomic subsequences and its application to viruses classification [PDF]

, 2016
Continuous improvements in next generation sequencing technologies led to ever-increasing collections of genomic sequences, which have not been easily characterized by biologists, and whose analysis requires huge computational effort.
Babakir Mina, Muhammed, Bertolazzi, Paola, Cella, Eleonora, Ciccozzi, Massimo, Ciotti, Marco, Felici, Giovanni, Fiscon, Giulia, Giovanetti, Marta, Lo Presti, Alessandra, Pierangeli, Alessandra, Weitschek, Emanuel   +10 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Author Correction: A B-ARR-mediated cytokinin transcriptional network directs hormone cross-regulation and shoot development

Nature Communications, 2018
The original version of this Article contained an error in Fig. 3. Panel b was inadvertently duplicated and the correct panel c was originally omitted. This error has been corrected in both the PDF and HTML versions of the Article.
Mingtang Xie, Hongyu Chen, Ling Huang, Ryan C. O’Neil, Maxim N. Shokhirev, Joseph R. Ecker   +5 more
doaj   +1 more source

Epigenetic silencing of a multifunctional plant stress regulator

eLife, 2019
The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2).
Mark Zander, Björn C Willige, Yupeng He, Thu A Nguyen, Amber E Langford, Ramlah Nehring, Elizabeth Howell, Robert McGrath, Anna Bartlett, Rosa Castanon, Joseph R Nery, Huaming Chen, Zhuzhu Zhang, Florian Jupe, Anna Stepanova, Robert J Schmitz, Mathew G Lewsey, Joanne Chory, Joseph R Ecker   +18 more
doaj   +1 more source

Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer. [PDF]

, 2019
Whole exome sequencing (WES), targeted gene panel sequencing and single nucleotide polymorphism (SNP) arrays are increasingly used for the identification of actionable alterations that are critical to cancer care.
Carpten, John D, Kaur, Pushpinder, Lang, Julie E, Porras, Tania B, Ring, Alexander   +4 more
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Catastrophic chromosomal restructuring during genome elimination in plants. [PDF]

, 2015
Genome instability is associated with mitotic errors and cancer. This phenomenon can lead to deleterious rearrangements, but also genetic novelty, and many questions regarding its genesis, fate and evolutionary role remain unanswered.
Bradnam, Keith R, Chan, Simon Wl, Comai, Luca, Henry, Isabelle M, Korf, Ian, Lysak, Martin A, Mandakova, Terezie, Marimuthu, Mohan Pa, Ravi, Maruthachalam, Tan, Ek Han   +9 more
core   +1 more source