Practitioner Review: Infant mental health meets cell and molecular biology – a look to the future
Background A major research effort in the past two decades has begun to illuminate how experience ‘gets under the skin’ – that is – the cellular and molecular processes that are associated with adversity and resilience. Methods We selectively review three areas of this research: epigenetics, especially DNA methylation, telomere length, and inflammatory
Charles H. Zeanah +3 more
wiley +1 more source
A quantitative genetic model for indirect genetic effects and genomic imprinting under random and assortative mating. [PDF]
Krätschmer I, Robinson MR.
europepmc +1 more source
Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung +6 more
wiley +1 more source
Bioinformatics insights into plant genomic imprinting: approaches, challenges, and future perspectives. [PDF]
Jing X, Su X, Zou Q, Niu M.
europepmc +1 more source
Features and mechanisms of canonical and noncanonical genomic imprinting. [PDF]
Hanna CW, Kelsey G.
europepmc +1 more source
Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang +8 more
wiley +1 more source
Advances and challenges of precision epigenetic therapy in treating genomic imprinting diseases. [PDF]
Lv Y, Li M, Ji C.
europepmc +1 more source
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang +9 more
wiley +1 more source
Loss of maternal PADI6 disrupts DNA methylation and genomic imprinting maintenance in late preimplantation mouse embryos. [PDF]
Giaccari C +9 more
europepmc +1 more source
Balanced gene dosage control rather than parental origin underpins genomic imprinting. [PDF]
Weinberg-Shukron A +7 more
europepmc +1 more source

