Results 11 to 20 of about 56,311 (230)
, 2021 AbstractA typical cell contains two sets of chromosomes: one that was inherited from the mother, the other from the father. Usually, autosomal alleles are expressed at similar levels from the maternally and paternally inherited chromosomes. This chapter is dedicated to an exception of this rule: the expression of genes that are regulated by genomic ...
Sharvari Deshpande +2 more
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Mammalian Genomic Imprinting [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Normal mammalian development requires a maternal and paternal contribution, which is attributed to imprinted genes, or genes that are expressed from a single parental allele. Approximately 100 imprinted genes have been reported in mammals thus far. Imprinted genes are controlled by cis-acting regulatory elements, termed imprinting control regions (ICRs)
Marisa S, Bartolomei +1 more
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Anales espanoles de pediatria, 1998 Abstract Certain genes demonstrate a parent-of-origin effect in their expression. This parent-of-origin effect occurs because these genes are modified during their transmission via oocytes or spermatocytes. The process of germ cell-specific modification of a gene is known as genomic imprinting, a term that was coined by Helen Crouse.
M, Moreno García, E, Barreiro Miranda
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Open Access Macedonian Journal of Medical Sciences, 2016 BACKGROUND: Genomic imprinting is the inheritance out of Mendelian borders. Many of inherited diseases and human development violates Mendelian law of inheritance, this way of inheriting is studied by epigenetics.AIM: The aim of this review is to analyze current opinions and options regarding to this way of inheriting.RESULTS: Epigenetics shows that ...
Bajrami, Emirjeta, Spiroski, Mirko
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Genomic Imprinting in Plants [PDF]
Epigenetics, 2008 Genomic imprinting attracted particular attention in the 1980’s following the discovery that the parental origin of genetic information is essential for normal development of eutherians1,2, for review see3. The term imprinting was first introduced in the 1960s to describe the elimination of the paternal chromosomes during spermatogenesis in the Sciarid
Olivier, Garnier +2 more
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Effects of reprogramming on genomic imprinting and the application of pluripotent stem cells
Stem Cell Research, 2019 Pluripotent stem cells are considered to be the ideal candidates for cell-based therapies in humans. In this regard, both nuclear transfer embryonic stem (ntES) cells and induced pluripotent stem (iPS) cells are particularly advantageous because patient ...
Xiajun Li +3 more
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Retinoblastoma makes its mark on imprinting in plants [PDF]
, 2008 Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Liliana M Costa +29 more
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Archives of Disease in Childhood, 1990 In the last few years, the importance of genomic imprinting as a basic biological phenomenon has become clear. Work from different areas has demonstrated that parent-of-origin differences in phenotype occur on a regular basis. This article summarizes some of the recent advances made in this field.
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DNA polymerase α (swi7) and the flap endonuclease fen1 (rad2) act together in the s-phase alkylation damage response in S. pombe [PDF]
, 2012 Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switching ...
Jacob Z. Dalgaard +5 more
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Genomic Imprinting Absent in Drosophila melanogaster Adult Females
Cell Reports, 2012 Genomic imprinting occurs when expression of an allele differs based on the sex of the parent that transmitted the allele. In D. melanogaster, imprinting can occur, but its impact on allelic expression genome-wide is unclear.
Joseph D. Coolon +4 more
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