Results 41 to 50 of about 24,778 (138)

Endosperm of Angiosperms and Genomic Imprinting

Life, 2020
Modern ideas about the role of epigenetic systems in the regulation of gene expression allow us to understand the mechanisms of vital activities in plants, such as genomic imprinting.
Elizabeth L. Kordyum, Sergei L. Mosyakin
doaj   +1 more source

Very small deletions within the NESP55 gene in pseudohypoparathyroidism type 1b

, 2014
Pseudohypoparathyroidism (PHP) is caused by reduced expression of genes within the GNAS cluster, resulting in parathormone resistance. The cluster contains multiple imprinted transcripts, including the stimulatory G protein α subunit (Gs-α) and NESP55 ...
Mackay, Deborah J.G., Poole, Rebecca L., Prescott, Trine, Rezwan, Faisal I., Temple, I. Karen, Walker, Joanna M.   +5 more
core   +1 more source

TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency. [PDF]

, 2018
Transition from primed to naive pluripotency is associated with dynamic changes in transposable element (TE) expression and demethylation of imprinting control regions (ICRs).
Chen, Pao-Yang, Chitiashvili, Tsotne, Clark, Amander T, Hosohama, Linzi, Kim, Rachel, Nakano, Atsushi, Nakano, Haruko, Tan, Yao Chang, Tao, Yu, Yen, Ming-Ren   +9 more
core   +2 more sources

Genomic imprinting beyond DNA methylation: a role for maternal histones

Genome Biology, 2017
Inheritance of DNA methylation states from gametes determines genomic imprinting in mammals. A new study shows that repressive chromatin in oocytes can also confer imprinting.
Courtney W. Hanna, Gavin Kelsey
doaj   +1 more source

Ectopic application of the repressive histone modification H3K9me2 establishes post-zygotic reproductive isolation in Arabidopsis thaliana [PDF]

, 2017
Hybrid seed lethality as a consequence of interspecies or interploidy hybridizations is a major mechanism of reproductive isolation in plants. This mechanism is manifested in the endosperm, a dosage-sensitive tissue supporting embryo growth.
De Jaeger, Geert, Gevaert, Kris, Jiang, Hua, Kohler, Claudia, Moreno-Romero, Jordi, Santos-Gonzalez, Juan, Van De Slijke, Eveline   +6 more
core   +1 more source

A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes

Cell Reports, 2015
Maternal genomic imprints are established during oogenesis. Histone deacetylases (HDACs) 1 and 2 are required for oocyte development in mouse, but their role in genomic imprinting is unknown.
Pengpeng Ma, Eric de Waal, Jamie R. Weaver, Marisa S. Bartolomei, Richard M. Schultz   +4 more
doaj   +1 more source

Use of Nasonia vitripennis to Evaluate Genomic Imprinting and Haplodiploid Inheritance [PDF]

, 2013
During fertilization, male and female gametes fuse and a diploid organism is generated. However, in some cases, not all of the genes from a parental genome are expressed.
Fisher, Carolyn
core   +1 more source

Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage. [PDF]

, 2020
During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized ...
Aljaber, Dana, Au, Dawn, Benmarhnia, Tarik, Cardiff, Robert D, Chavez, Tanya, Dietze, Eric C, Doan, Stacey, Jankowska, Marta M, Jones, Veronica, McCune, Jeannine S, Natarajan, Rama, Nunez, Alan, Resto, Cristal, Sanchez, Angelica, Seewaldt, Victoria L, Serrano, Mayra, Sistrunk, Christopher, Thai, Christine, Tomsic, Jerneja, Yang, Jiue-An   +19 more
core   +1 more source

Detection of DNA methylation signatures through the lens of genomic imprinting

Scientific Reports
Genomic imprinting represents an original model of epigenetic regulation resulting in a parent-of-origin expression. Despite the critical role of imprinted genes in mammalian growth, metabolism and neuronal function, there is no molecular tool ...
Jean-Noël Hubert, Nathalie Iannuccelli, Cédric Cabau, Eva Jacomet, Yvon Billon, Rémy-Félix Serre, Céline Vandecasteele, Cécile Donnadieu, Julie Demars   +8 more
doaj   +1 more source

Roles of retrovirus-derived PEG10 and PEG11/RTL1 in mammalian development and evolution and their involvement in human disease

Frontiers in Cell and Developmental Biology, 2023
PEG10 and PEG11/RTL1 are paternally expressed, imprinted genes that play essential roles in the current eutherian developmental system and are therefore associated with developmental abnormalities caused by aberrant genomic imprinting.
Hirosuke Shiura, Moe Kitazawa, Fumitoshi Ishino, Tomoko Kaneko-Ishino   +3 more
doaj   +1 more source