Results 51 to 60 of about 538,877 (242)

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Sequencing data: A genomic network to monitor Earth

, 2012
We propose that a network of genomic observatories should be established to take the planet's 'biological pulse'. We invite participants to assist in the shaping of this network (see genomicobservatories.org).
Field, D., The Genomic Observatories Network, Neil Davies, Hirsch, P. R., The Genomic Observatories Network, ., The Genomic Observatories Network,, Davies, N., Field, Dawn, Bates, N., Dawn Field, Davies, Neil   +10 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

A comprehensive overview of genomic imprinting in breast and its deregulation in cancer

Nature Communications, 2018
In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying ...
Tine Goovaerts, Sandra Steyaert, Chari A. Vandenbussche, Jeroen Galle, Olivier Thas, Wim Van Criekinge, Tim De Meyer   +6 more
doaj   +1 more source

Role of genomic imprinting in mammalian development

, 2020
Non-mendelian inheritance refers to the group of phenomena and observations related to the inheritance of genetic information that cannot be merely explained by Mendel’s laws of inheritance.
Khosla, Sanjeev, Agarwaal, Viplove, Thamban, Thushara   +2 more
core   +1 more source

Sexual imprinting as a two-stage process: mechanisms of information storage and stabilization [PDF]

, 1995
Oetting S, Proeve E, Bischof H-J. Sexual imprinting as a two-stage process: mechanisms of information storage and stabilization. Animal Behaviour. 1995;50(2):393-403.Sexual imprinting occurs in two stages, an acquisition phase when the birds learn about ...
Proeve, Ekkehard, Oetting, Sabine, Bischof, Hans-Joachim   +2 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Genomic Imprinting: Parental Influence on the Genome

, 2001
GENOMIC IMPRINTING: PARENTAL INFLUENCE ON THE GENOME Genomic Imprinting: Parental Influence on the Genome (2) (-
Reik, Wolf Jorn Walter
core   +2 more sources

Mosaic Analysis with Double Markers Reveals Cell-Type-Specific Paternal Growth Dominance

Cell Reports, 2013
Genomic imprinting leads to preferred expression of either the maternal or paternal alleles of a subset of genes. Imprinting is essential for mammalian development, and its deregulation causes many diseases.
Simon Hippenmeyer, Randy L. Johnson, Liqun Luo   +2 more
doaj   +1 more source

Syndromic Disorders Caused by Disturbed Human Imprinting

JCRPE, 2020
Imprinting disorders are a group of congenital diseases caused by dysregulation of genomic imprinting, affecting prenatal and postnatal growth, neurocognitive development, metabolism and cancer predisposition.
Diana Carli, Evelise Riberi, Giovanni Battista Ferrero, Alessandro Mussa   +3 more
doaj   +1 more source