Results 31 to 40 of about 33,170 (247)
Sex dependent imprinting effects on complex traits in mice
BMC Evolutionary Biology, 2008 Background Genomic imprinting is an epigenetic source of variation in quantitative traits that results from monoallelic gene expression, where commonly either only the paternally- or the maternally-derived allele is expressed.
Leamy Larry J +3 more
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The Role of Long Non-coding RNAs in Human Imprinting Disorders: Prospective Therapeutic Targets
Frontiers in Cell and Developmental Biology, 2021 Genomic imprinting is a term used for an intergenerational epigenetic inheritance and involves a subset of genes expressed in a parent-of-origin-dependent way.
Tingxuan Wang +4 more
doaj +1 more source
Mammalian Genomic Imprinting [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Normal mammalian development requires a maternal and paternal contribution, which is attributed to imprinted genes, or genes that are expressed from a single parental allele. Approximately 100 imprinted genes have been reported in mammals thus far. Imprinted genes are controlled by cis-acting regulatory elements, termed imprinting control regions (ICRs)
Marisa S, Bartolomei +1 more
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The Evolution of Genomic Imprinting [PDF]
Genetics, 1996 Abstract In some mammalian genes, the paternally and maternally derived alleles are expressed differently: this phenomenon is called genomic imprinting. Here we study the evolution of imprinting using multivariate quantitative genetic models to examine the feasibility of the genetic conflict hypothesis.
A, Mochizuki, Y, Takeda, Y, Iwasa
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Characterisation of marsupial
BMC Evolutionary Biology, 2011 Background Genomic imprinting causes parent-of-origin specific gene expression by differential epigenetic modifications between two parental genomes. We previously reported that there is no evidence of genomic imprinting of CDKN1C in the KCNQ1 domain in ...
Shaw Geoffrey +4 more
doaj +1 more source
Genomic imprinting beyond DNA methylation: a role for maternal histones
Genome Biology, 2017 Inheritance of DNA methylation states from gametes determines genomic imprinting in mammals. A new study shows that repressive chromatin in oocytes can also confer imprinting.
Courtney W. Hanna, Gavin Kelsey
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Advanced Materials Technologies, EarlyView.ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali +4 more
wiley +1 more source
A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes
Cell Reports, 2015 Maternal genomic imprints are established during oogenesis. Histone deacetylases (HDACs) 1 and 2 are required for oocyte development in mouse, but their role in genomic imprinting is unknown.
Pengpeng Ma +4 more
doaj +1 more source
Retrotransposition and genomic imprinting [PDF]
Briefings in Functional Genomics, 2010 Studies of large imprinted clusters, such as the Gnas locus, have revealed much about the significance of DNA methylation, transcription and other factors in the establishment and maintenance of imprinted gene expression. However, the complexity of such loci can make manipulating them and interpreting the results challenging.
Cowley, Michael, Oakey, Rebecca J.
openaire +3 more sources