Results 11 to 20 of about 24,778 (138)

Effects of reprogramming on genomic imprinting and the application of pluripotent stem cells

Stem Cell Research, 2019
Pluripotent stem cells are considered to be the ideal candidates for cell-based therapies in humans. In this regard, both nuclear transfer embryonic stem (ntES) cells and induced pluripotent stem (iPS) cells are particularly advantageous because patient ...
Xiajun Li, Max Jiahua Li, Yang Yang, Yun Bai   +3 more
doaj   +1 more source

Retinoblastoma makes its mark on imprinting in plants [PDF]

, 2008
Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Liliana M Costa, José F Gutierrez-Marcos, Wolf, Youngson, Spillane, Kermicle, Feil, Delaval, Bourc&apos, Schoenherr, Mager, Lewis, Gutierrez-Marcos, Kinoshita, Jullien, Choi, Morales-Ruiz, Reik, McCabe, Jung, Ebel, Hennig, Guitton, Ingouff, Jullien, Kimura, Rossi, Wu, Mathieu, Wu   +29 more
core   +2 more sources

Genomic imprinting. [PDF]

Archives of Disease in Childhood, 1990
In the last few years, the importance of genomic imprinting as a basic biological phenomenon has become clear. Work from different areas has demonstrated that parent-of-origin differences in phenotype occur on a regular basis. This article summarizes some of the recent advances made in this field.
openaire   +3 more sources

Genomic Imprinting Absent in Drosophila melanogaster Adult Females

Cell Reports, 2012
Genomic imprinting occurs when expression of an allele differs based on the sex of the parent that transmitted the allele. In D. melanogaster, imprinting can occur, but its impact on allelic expression genome-wide is unclear.
Joseph D. Coolon, Kraig R. Stevenson, C. Joel McManus, Brenton R. Graveley, Patricia J. Wittkopp   +4 more
doaj   +1 more source

Genomic Imprinting in the New Omics Era: A Model for Systems-Level Approaches

Frontiers in Genetics, 2022
Genomic imprinting represents a noteworthy inheritance mechanism leading to allele-specific regulations dependent of the parental origin. Imprinted loci are especially involved in essential mammalian functions related to growth, development and behavior.
Jean-Noël Hubert, Julie Demars
doaj   +1 more source

Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies

The Innovation, 2023
Genomic imprinting can lead to allele-specific expression (ASE), where one allele is preferentially expressed more than the other. Perturbations in genomic imprinting or ASE genes have been widely observed across various neurological disorders, notably ...
Zongyang Lu, Jie Li, Yong Lu, Ling Li, Wei Wang, Chenchen Zhang, Libing Xu, Yanhong Nie, Changshan Gao, Xinyan Bian, Zhen Liu, Guang-Zhong Wang, Qiang Sun   +12 more
doaj   +1 more source

Genomic imprinting effects on complex traits in domesticated animal species

Frontiers in Genetics, 2015
Monoallelically expressed genes that exert their phenotypic effect in a parent-of-origin specific manner are considered to be subject to genomic imprinting, the most well understood form of epigenetic regulation of gene expression in mammals.
Alan eO'Doherty, David eMacHugh, Charles eSpillane, David eMagee   +3 more
doaj   +1 more source

The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis. [PDF]

, 2019
The Arabidopsis DEMETER (DME) DNA glycosylase demethylates the maternal genome in the central cell prior to fertilization and is essential for seed viability.
Aravind, L., Fischer, Robert L., Frost, Jennifer M., Hsieh, Tzung-Fu, Huh, Jin Hoe, Hung, Yu-Hung, Iyer, Lakshminarayan M., Jang, Hosung, Liu, Fang, Rim, Hyun Jung, Shin, Hosub, Xiao, Wenyan, Zhang, Changqing, Zhang, Dapeng, Zhang, Xiang-Qian, 허진회   +15 more
core   +2 more sources

Next-Generation Sequencing Techniques Reveal that Genomic Imprinting Is Absent in Day-Old Gallus gallus domesticus Brains.

PLoS ONE, 2015
Genomic imprinting is a phenomenon characterized by parent-of-origin-specific gene expression. While widely documented in viviparous mammals and plants, imprinting in oviparous birds remains controversial.
Qiong Wang, Kaiyang Li, Daixi Zhang, Junying Li, Guiyun Xu, Jiangxia Zheng, Ning Yang, Lujiang Qu   +7 more
doaj   +1 more source

New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism, but not in suckling [PDF]

, 2012
The imprinted Gnas cluster is involved in obesity, energy metabolism, feeding behavior, and viability. Relative contribution of paternally expressed proteins XLαs, XLN1, and ALEX or a double dose of maternally expressed Gsα to phenotype has not been ...
Abramowitz J, Balthasar N, Bamshad M, Bartness TJ, Bastepe M, Bastepe M, Baxendale RW, Bunting M, Castrop H, Cattanach BM, Cattanach BM, Chen M, Chen M, Chen M, Chotalia M, Crawford JA, de Bovis B, de Paula FJ, Ducy P, Elefteriou F, Friedman JM, Fu L, Fukao M, Germain-Lee EL, Hayward BE, Holmes R, Ivanova E, Kawai M, Kaya AI, Kehlenbach RH, Kelly ML, Kelsey G, Klemke M, Klemke M, Kublaoui BM, Lam DD, Liu J, Maffei M, Moore T, Oswal A, Pasolli HA, Pasolli HA, Peters J, Peters J, Peters J, Plagge A, Plagge A, Sakamoto A, Sakamoto A, Schmidt-Nielsen K, Shin JY, Shrestha YB, Skinner JA, Sleutels F, Storck T, Weinstein LS, Weinstein LS, Williamson CM, Williamson CM, Williamson CM, Wroe SF, Xie T, Yadav VK, Youngstrom TG, Yu S, Yu S   +65 more
core   +1 more source