Results 61 to 70 of about 56,311 (230)

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

A comprehensive overview of genomic imprinting in breast and its deregulation in cancer

Nature Communications, 2018
In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying ...
Tine Goovaerts, Sandra Steyaert, Chari A. Vandenbussche, Jeroen Galle, Olivier Thas, Wim Van Criekinge, Tim De Meyer   +6 more
doaj   +1 more source

Thermal imprinting modifies adult stress and innate immune responsiveness in the teleost sea bream [PDF]

, 2017
The impact of thermal imprinting on the plasticity of the hypothalamic-pituitary-interrenal (HPI) axis and stress response in an adult ectotherm, the gilthead sea bream (Sparus aurata, L.), during its development was assessed.
A Costa, Rita, Andree, Karl B., Cardoso, João CR, Estevez, Alicia, Gisbert, Enric, Mateus, Ana, Power, Deborah   +6 more
core   +1 more source

Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities

Journal of Periodontology, EarlyView.
Abstract Historically, immunological memory was considered an exclusive feature of adaptive immunity. However, innate immune cells have recently been shown to record and maintain epigenetically imprinted memory of earlier infectious or inflammatory challenges.
George Hajishengallis
wiley   +1 more source

Mosaic Analysis with Double Markers Reveals Cell-Type-Specific Paternal Growth Dominance

Cell Reports, 2013
Genomic imprinting leads to preferred expression of either the maternal or paternal alleles of a subset of genes. Imprinting is essential for mammalian development, and its deregulation causes many diseases.
Simon Hippenmeyer, Randy L. Johnson, Liqun Luo   +2 more
doaj   +1 more source

Syndromic Disorders Caused by Disturbed Human Imprinting

JCRPE, 2020
Imprinting disorders are a group of congenital diseases caused by dysregulation of genomic imprinting, affecting prenatal and postnatal growth, neurocognitive development, metabolism and cancer predisposition.
Diana Carli, Evelise Riberi, Giovanni Battista Ferrero, Alessandro Mussa   +3 more
doaj   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

Cell-cell communication-mediated cell-type-specific parent-of-origin effects in mammals

Nature Communications
Genomic imprinting is manifested as monoallelic expression of genes according to parental origin, which is closely linked to mammalian placentation and human diseases. Yet, it is unclear how genomic imprinting evolves in different cell types.
Jia-Jin Wu, Enqin Zheng, Langqing Liu, Jianping Quan, Donglin Ruan, Zekai Yao, Jifei Yang, Xuehua Li, Shiyuan Wang, Ming Yang, Zebin Zhang, Meng Lin, Zheng Xu, Zicong Li, Gengyuan Cai, Jie Yang, Zhenfang Wu   +16 more
doaj   +1 more source

Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta

Obstetrics and Gynecology International, 2010
Case reports from infant twins suggest that abnormal genomic imprinting may be one of the important causes of twin discordance, but it is unknown whether abnormal genomic imprinting occurs in the placenta.
Yan-Min Luo, Qun Fang, Hui-Juan Shi, Lin-Huan Huang, Run-Cai Liang, Guang-Lun Zhuang   +5 more
doaj   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source