Results 181 to 190 of about 120,679 (294)

Advancing toxicity AI-based prediction with multilevel systems biology: a case study on genotoxicity. [PDF]

Brief Bioinform
Zhang X, Zhang H, Yun X, Pan W, Xue Q, Liu X, Fu J, Zhang A.   +7 more
europepmc   +1 more source

Genotoxicity and Cytotoxicity of novel 10B carrier ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid

, 2019
Zafer Akan, Hülya Özdemir, Gökhan Oto, Sabahattin Deniz, Ömer Kaçar, Ali Sadi Başak, Tahir Çakır, Hatice Uslu Sinav, Göksel Demir   +8 more
openalex   +1 more source

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, EarlyView.
What's New? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

RETRACTION: Roles of <i>Moringa oleifera</i> Leaf Extract in Improving the Impact of High Dietary Intake of Monosodium Glutamate-Induced Liver Toxicity, Oxidative Stress, Genotoxicity, DNA Damage, and PCNA Alterations in Male Rats. [PDF]

Oxid Med Cell Longev
Cellular Longevity OMA.
europepmc   +1 more source

Genotoxic and antigenotoxic potential of encapsulated Enhalus acoroides (L. f.) Royle leaves extract against nickel nitrate

, 2022
Made Pharmawati, Ni Nyoman Wirasiti, Luh Putu Wrasiati   +2 more
openalex   +2 more sources

Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing

iMetaMed, EarlyView.
Amyloid precursor protein (APP)‐mediated endothelial‐immune cell crosstalk is a novel mechanism for potassium sorbate‐induced renal injury. Multi‐omics integration (network toxicology, machine learning, scRNA‐seq) uncovers this interaction via APP‐CD74/PTGER2 axes, linking oxidative stress and inflammation to renal damage. ABSTRACT Acute kidney injury (
Yimao Wu, Yalun Liang, Jintao Liang, Gokhan Zengin, Qian Zhang, Meng‐Yao Li   +5 more
wiley   +1 more source

TGx-DDI (toxicogenomic DNA damage-inducing) biomarker validation: multi-site ring trial supporting regulatory use. [PDF]

Toxicol Sci
Wang X, Crute CE, Allemang A, Aubrecht J, Burleson F, Dietz-Baum Y, Dorsheimer L, Fornace AJ, Frötschl R, Hemmann U, Mitchell CA, Pfuhler S, Williams A, Lin LY, Pettit S, Yauk CL, Li HH.   +16 more
europepmc   +1 more source

High-throughput metabolic genotoxicity screening with a fluidic microwell chip and electrochemiluminescence

, 2013
Dhanuka P. Wasalathanthri, Spundana Malla, Itti Bist, Chi Kwong Tang, Ronaldo C. Faria, James F. Rusling   +5 more
openalex   +1 more source

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source

From Vision to Reality: Five Years of the Botanical Safety Consortium. [PDF]

Pharm Biol
Mitchell CA, Roe AL, Auerbach S, Bascoul C, Embry M, Ferguson S, Gafner S, Gossmann M, Gurley BJ, Johnson H, Kelber O, Krzykwa J, Larson J, Liu Y, Mahony C, Monteiro da Rocha A, Pfuhler S, Sica V, Waidyanatha S, Westerink RHS, Witt K, Oketch-Rabah H, Rider C.   +22 more
europepmc   +1 more source