Results 31 to 40 of about 35,705 (247)

Hospital Wastewater Genotoxicity [PDF]

The Annals of Occupational Hygiene, 2005
Hospitals represent an incontestable release source of many chemicals compounds in their wastewaters, and which may have an impact on the environment and human health. Indeed, some of the substances found in wastewaters are genotoxic and are suspected to be a possible cause of the cancers observed in the last decades. To study the toxicity and the risk
B, Jolibois, M, Guerbet
openaire   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Rapid and Accurate Genotoxicity Assessment Using the Neutral Comet Assay in Cyprinus carpio Cells

Life
Genotoxins cause significant damage to the genetic material of aquatic organisms, requiring rapid and accurate assessment. Fish-derived cells sensitive to genotoxins have proven to be a useful tool for measuring genotoxicity, but the long treatment times
Byeonghyeon So, Ji Ho Park, Minseon Kim, Hojun Lee, Jee Hee Yoon, Yoo Jin Lee, Duyeol Kim, Hyung Wook Kwon, Jihae Park, Taejun Han, Yun Haeng Lee, Joon Tae Park   +11 more
doaj   +1 more source

Allium test genotoxicity data on water from river valley of Irtysh, West Siberia

Data in Brief, 2022
Assessment of genotoxicity of aquatic ecosystems is of great importance for environmental management and assessment of water ecological quality as well as health safety.Data on the genotoxicity of water in rivers of such a large region as Siberia are ...
Dmitry S. Pesnya, Sergey E. Bolotov
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Mechanisms and Assessment of Genotoxicity of Metallic Engineered Nanomaterials in the Human Environment

Biomedicines
Engineered nanomaterials (ENMs) have a broad array of applications in agriculture, engineering, manufacturing, and medicine. Decades of toxicology research have demonstrated that ENMs can cause genotoxic effects on bacteria, mammalian cells, and animals.
Benjamin M. Liu, A. Wallace Hayes
doaj   +1 more source

Scientific opinion on the renewal of the authorisation of proFagus Smoke R709 (SF‐008) as a smoke flavouring Primary Product

EFSA Journal, 2023
The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of the smoke flavouring Primary Product proFagus Smoke R709 (SF‐008), for which a renewal application was submitted in accordance with Article 12(1) of Regulation
EFSA Panel name on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Polly Boon, Claudia Bolognesi, Eugenia Cordelli, Kevin Chipman, Gisela Degen, Ullrika Sahlin, Maria Carfì, Carla Martino, Agnieszka Mech, Salvatore Multari, Vasantha Palaniappan, Alexandra Tard, Wim Mennes   +31 more
doaj   +1 more source

Signs of deferasirox genotoxicity [PDF]

Cytotechnology, 2013
Iron overload is a major health problem for patients who have to have continuous blood transfusions. It brings some metabolic problems together. Various iron chelating agents are being used for treatment of hemochromatosis which arises from excess iron accumulation.
Ila, Hasan Basri, Topaktas, Mehmet, Arslan, Mehmet, Buyukleyla, Mehmet   +3 more
openaire   +4 more sources