Results 91 to 100 of about 5,436,069 (302)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Challenges and advances in mycobacterial molecular typing

Annals of Clinical Microbiology
Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM) present distinct clinical and epidemiological challenges and thus require tailored genotyping approaches.
Minh Phuong Trinh, Min-Kyoung Shin
doaj   +1 more source

Advances in Single-Cell Techniques for Linking Phenotypes to Genotypes

Cancer Heterogeneity and Plasticity
Single-cell analysis has become an essential tool in modern biological research, providing unprecedented insights into cellular behavior and heterogeneity. By examining individual cells, this approach surpasses conventional population-based methods, revealing critical variations in cellular states, responses to environmental cues, and molecular ...
Hsiao-Chun, Chen, Yushu, Ma, Jinxiong, Cheng, Yu-Chih, Chen   +3 more
openaire   +2 more sources

Genotyping-by-sequencing

, 2016
Genotyping-by-sequencing: Emerging alternative technology to array based genotyping for GBLUP & GWAS. Two “categories” - oligo directed re-sequencing of specific regions -targeted; reduced representational re-sequencing- restriction enzyme digests ...
Ken Dodds (3501542), Rudiger Brauning (47247), Shannon Clarke (3504989), John McEwan (45371)   +3 more
core  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Modified MLVA for Genotyping Queensland Invasive Streptococcus pneumoniae.

PLoS ONE, 2015
BackgroundGlobally, over 800 000 children under five die each year from infectious diseases caused by Streptococcus pneumoniae. To understand genetic relatedness between isolates, study transmission routes, assess the impact of human interventions e.g ...
Rachael E Rayner, John Savill, Louise M Hafner, Flavia Huygens   +3 more
doaj   +1 more source

Using the R Package crlmm for Genotyping and Copy Number Estimation [PDF]

Genotyping platforms such as Affymetrix can be used to assess genotype-phenotype as well as copy number-phenotype associations at millions of markers.
Rafael A. Irizarry, Matthew E. Ritchie, Ingo Ruczinski, Robert B. Scharpf, Benilton Carvalho   +4 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Evaluating genotyping‐in‐thousands by sequencing as a genetic monitoring tool for a climate sentinel mammal using non‐invasive and archival samples

Ecology and Evolution
Genetic tools for wildlife monitoring can provide valuable information on spatiotemporal population trends and connectivity, particularly in systems experiencing rapid environmental change.
Kate E. Arpin, Danielle A. Schmidt, Bryson M. F. Sjodin, Anthony L. Einfeldt, Kurt Galbreath, Michael A. Russello   +5 more
doaj   +1 more source

Similarity in food cleaning techniques within matrilines in wild vervet monkeys [PDF]

, 2012
Social learning and the formation of traditions rely on the ability and willingness to copy one another. A central question is under which conditions individuals adapt behaviour to social influences.
Krützen, Michael, Jérôme Goudet (169498), Hula Josephine, Kruetzen, Michael, Redouan Bshary (82817), van de Waal, Erica, Bshary Redouan, Hula, Josephine, Erica van de Waal, van de Waal, E., Goudet, Jérôme, Michael Krützen (118662), Erica van de Waal (169461), Goudet Jérôme, Bshary, R., Josephine Hula (169484), Goudet, J., Jérôme Goudet, Michael Krützen, van de Waal Erica, Krützen Michael, Krützen, M., Josephine Hula, Redouan Bshary, Bshary, Redouan, Hula, J.   +25 more
core   +2 more sources