Results 91 to 100 of about 11,640,365 (320)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A review of evidence on non-invasive prenatal diagnosis (NIPD) : tests for fetal RHD genotype [PDF]

, 2007
This report concentrates on three main areas. First and foremost, we set the background context for RhD NIPD in prenatal care. While the methodology chapter describes how the literature review was carried out and how additional information was collected,
Clay, Diane, Freeman, Karoline, HASH(0x55aa091d4640), Hyde, Julia, Osipenko, Leeza, Szczepura, Ala   +5 more
core  

A novel technique for rapid automated genotyping of DNA polymorphisms in the mouse

Molecular and Cellular Probes, 1999
The ability to rapidly and reliably genotype mice is an important concern. Traditional methods employ labour intensive and time consuming techniques such as test crossing, gel electrophoresis or nucleic acid hybridization. Here we show that a new molecular biology workstation, the WAVE DNA Fragment Analysis System, can easily resolve polymerase chain ...
A, Kuklin, A P, Davis, K H, Hecker, D T, Gjerde, P D, Taylor   +4 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The Identification of Pompe Disease Mutations in Archival Tissues and Development of a Rapid Molecular-based Test

Sultan Qaboos University Medical Journal, 2013
Objectives: Pompe disease (glycogen storage disease type II) is a rare autosomal recessive lysosomal storage disease that is caused by acid alpha-glucosidase deficiency.
Aliya Alansari, Samira Al-Rawahi, Taher Ba-Omar, Mariam Al-Nabhani, Anand Date   +4 more
doaj  

GENOTYPING OF THE HUMAN IMMUNODEFICIENCY VIRUS AND PATTERNS OF RESISTANCE TO ANTIRETROVIRALS IN SOUTHERN SANTA CATARINA

Brazilian Journal of Infectious Diseases
Introduction/Objectives: The Human Immunodeficiency Virus (HIV), which can cause AIDS, remains a major global public health issue. Therapeutic advances have succeeded in increasing survival and improving the quality of life of patients living with the ...
Chaiana Esmeraldino Mendes Marcon, Allyson Maciel Candido, Laís Villa Demétrio, Danilo Assunção, Alessandra Machado Cordella, Aline Daiane Schlindwein, Fabiana Schuelter Trevisol   +6 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Smart breeding driven by advances in sequencing technology

Modern Agriculture, 2023
Crop breeding has undergone numerous advancements throughout history with the next revolution being uncertain. This review provides an overview of breeding techniques from traditional selective breeding and crossbreeding to modern breeding based on ...
Chenji Zhang, Sirong Jiang, Yangyang Tian, Xiaorui Dong, Jianjia Xiao, Yanjie Lu, Tiyun Liang, Hongmei Zhou, Dabin Xu, Han Zhang, Ming Luo, Zhiqiang Xia   +11 more
doaj   +1 more source

Estimation of pedigree errors in the UK dairy population using microsatellite markers and the impact on selection [PDF]

, 2002
The proportion of cows in the UK dairy herd whose sires were misidentified was estimated using DNA markers. Genetic marker genotypes were determined on 568 cows (from 168 milk samples and 400 hair samples) and 96 putative sires (from semen samples).
Smith, D., Visscher, Peter, Williams, J.L., Woolliams, John   +3 more
core   +1 more source

Preservation of a rare bog pine genotypes using micropropagation techniques

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2014
Bog pine (Pinus uncinata DC. subsp. uliginosa (Neumann) Businský) is a subendemic species and appears to be one of the most endangered tree species of the Czech Republic. Its rare populations are at the present time greatly endangered namely by spontaneous hybridization with the Scots pine (Pinus sylvestris L.).
Hana Vejsadová, Helena Vlašínová, Ladislav Havel   +2 more
openaire   +2 more sources