Results 71 to 80 of about 83,652 (291)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genomic Characterization of the Vaccinal Strain of Mycobacterium Avium Subspecies Paratuberculosis (MAP) 316F by MIRU-VNTR

Medical Laboratory Journal, 2015
Background and Objective: Paratuberculosis is a chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). this study aimed to characterize the genome of the MAP 316F strain.
Zahra Ebrahim, Keyvan Tadayon, Nader Mosavari   +2 more
doaj  

Discovering and Genotyping Twilight Zone Deletions [PDF]

, 2016
This chapter focuses on techniques for next-generation resequencing studies, which allow to study the differences between a donor genome, a genome to be investigated, and a reference genome.
Marschall, T. (Tobias), Schönhuth, Alexander, Marschall, Tobias, Tobias Marschall, Alexander Schönhuth, Schönhuth, A. (Alexander)   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Variant Genotyping with Gap Filling

, 2017
Although recent developments in DNA sequencing have allowed for great leaps in both the quality and quantity of genome assembly projects, de novo assemblies still lack the efficiency and accuracy required for studying individual genomes.
Walve, Riku
core   +2 more sources

GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing

Communications Biology, 2022
GAWMerge is a computational tool that allows users to integrate SNP genotyping data from array techniques or whole-genome sequencing, providing a feasible method to leverage existing cohorts to increase sample size in genetic studies.
Ravi Mathur, Fang Fang, Nathan Gaddis, Dana B. Hancock, Michael H. Cho, John E. Hokanson, Laura J. Bierut, Sharon M. Lutz, Kendra Young, Albert V. Smith, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Edwin K. Silverman, Grier P. Page, Eric O. Johnson   +13 more
doaj   +1 more source

A novel technique for rapid automated genotyping of DNA polymorphisms in the mouse

Molecular and Cellular Probes, 1999
The ability to rapidly and reliably genotype mice is an important concern. Traditional methods employ labour intensive and time consuming techniques such as test crossing, gel electrophoresis or nucleic acid hybridization. Here we show that a new molecular biology workstation, the WAVE DNA Fragment Analysis System, can easily resolve polymerase chain ...
A, Kuklin, A P, Davis, K H, Hecker, D T, Gjerde, P D, Taylor   +4 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Identification of Pompe Disease Mutations in Archival Tissues and Development of a Rapid Molecular-based Test

Sultan Qaboos University Medical Journal, 2013
Objectives: Pompe disease (glycogen storage disease type II) is a rare autosomal recessive lysosomal storage disease that is caused by acid alpha-glucosidase deficiency.
Aliya Alansari, Samira Al-Rawahi, Taher Ba-Omar, Mariam Al-Nabhani, Anand Date   +4 more
doaj  

GENOTYPING OF THE HUMAN IMMUNODEFICIENCY VIRUS AND PATTERNS OF RESISTANCE TO ANTIRETROVIRALS IN SOUTHERN SANTA CATARINA

Brazilian Journal of Infectious Diseases
Introduction/Objectives: The Human Immunodeficiency Virus (HIV), which can cause AIDS, remains a major global public health issue. Therapeutic advances have succeeded in increasing survival and improving the quality of life of patients living with the ...
Chaiana Esmeraldino Mendes Marcon, Allyson Maciel Candido, Laís Villa Demétrio, Danilo Assunção, Alessandra Machado Cordella, Aline Daiane Schlindwein, Fabiana Schuelter Trevisol   +6 more
doaj   +1 more source