Results 51 to 60 of about 5,436,069 (302)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

High-throughput high-resolution class I HLA genotyping in East Africa. [PDF]

, 2010
HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses. A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria,
Leonard Maboko, Eller, Michael, Jerome Kim, Rebecca N Koehler, Francine E McCutchan, Michael Eller, Christian T Bautista, Hoelscher Michael, Eller, Leigh Anne, Jeffrey R Currier, Currier Jeffrey R., Nelson L Michael, Michael, Nelson L., Kijak, Gustavo H, Maboko Leonard, Michael, Nelson L, McCutchan, Francine E., Michael Nelson L., Maboko, Leonard, Walsh, Anne M, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Currier, Jeffrey R, Eller Michael, McCutchan, Francine E, Eric E Sanders-Buell, Sanders-Buell, Eric E., Robb, Merlin L, Robb Merlin L., Kijak Gustavo H., Leigh Anne Eller, Kim Jerome, Robb, Merlin L., Bautista Christian T., Anne M Walsh, Hoelscher, Michael, Kijak, Gustavo H., Bautista, Christian T, Michael Hoelscher, McCutchan Francine E., Kim, Jerome, Eller Leigh Anne, Koehler, Rebecca N, Merlin L Robb, Bautista, Christian T., Koehler, Rebecca N., Koehler Rebecca N., Sanders-Buell, Eric E, Sanders-Buell Eric E., Walsh, Anne M., Currier, Jeffrey R., Gustavo H Kijak, Walsh Anne M.   +53 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Individual Identification of Cartilage by Direct Amplification in Mass Disasters [PDF]

Fayixue Zazhi, 2017
Objective To explore the effectiveness of direct amplification for the STR analysis of cartilage, and to accelerate the effectiveness of disaster victim identification.
WANG CHUAN-HAI, XU CHENG, LI XIANG-QIN, ET AL.
doaj   +1 more source

"Plasmodium falciparum" Drug Resistance, Molecular Genotyping and Generation of a Malaria Resistance Genogram by DNA Microarray-Based Technology [PDF]

, 2006
Prior to the 2001 malarial treatment policy change in Tanzania, studies were conducted to assess the efficacy of sulfadoxine-pyrimethamine (SP) and usefulness of molecular markers in monitoring SP resistance.
Mugittu, Kefas Nasongelya
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Dealing with AFLP genotyping errors to reveal genetic structure in Plukenetia volubilis (Euphorbiaceae) in the Peruvian Amazon.

PLoS ONE, 2017
An analysis of the population structure and genetic diversity for any organism often depends on one or more molecular marker techniques. Nonetheless, these techniques are not absolutely reliable because of various sources of errors arising during the ...
Jakub Vašek, Petra Hlásná Čepková, Iva Viehmannová, Martin Ocelák, Danter Cachique Huansi, Pavel Vejl   +5 more
doaj   +1 more source

Plasmodium falciparum population dynamics during the early phase of anti-malarial drug treatment in Tanzanian children with acute uncomplicated malaria. [PDF]

, 2011
BACKGROUND\ud \ud This study aimed to explore Plasmodium falciparum population dynamics during the early phase of anti-malarial drug treatment with artemisinin-based combination therapy in children with clinical malaria in a high transmission area in ...
Carlsson, A.M, Abdulla, Salim, Christopher Membi, Veiga, I.M, Ngasala, Billy E, Gil, J Pedro, Abdulla, S., Carlsson, Anja M, Premji, Z., Björkman, Anders, Premji, Zul, Dahlström, Sabina, Veiga, I.M., Carlsson, Anja M., Anders Björkman, Abdulla Salim, Ngasala, B.E, Lars Rombo, Billy E Ngasala, Veiga, Isabel M, Gil, J. P., Björkman Anders, Zul Premji, Membi, Christopher, Mårtensson, Andreas, Ngasala, Billy E., Bjorkman, A., Martensson, A., Salim Abdulla, Isabel M Veiga, Mårtensson Andreas, Gil J, Ngasala Billy E, Gil, J.P., Rombo, L., Premji Zul, Rombo Lars, Carlsson Anja M, Andreas Mårtensson, Membi Christopher, Anja M Carlsson, Dahlstrom, S., Membi, C., Rombo, Lars,, Carlsson, A.M., Sabina Dahlström, J Gil, Dahlström Sabina, Veiga, Maria Isabel, Rombo, Lars, Veiga Isabel M, Ngasala, B.E.   +51 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source