Results 61 to 70 of about 11,640,365 (320)

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Application of individualized therapy based on molecular classification in the treatment of medulloblastoma in children

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To explore the clinical efficacy of individualized therapy based on molecular classification in the treatment of medulloblastoma in children.
Wei SHI, Ping XUE, Jian⁃zhong YU, Rui ZHAO, Yi ZHANG, Hao LI   +5 more
doaj  

Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians [PDF]

, 2003
The naturally mummified remains of a mother and two daughters found in an 18th century Hungarian crypt were analysed, using multiple molecular genetic techniques to examine the epidemiology and evolution of tuberculosis.
Donoghue, H.D., Fletcher, H.A., Spigelman, M., Taylor, G.M., van der Zanden, A.G.M.   +4 more
core  

Mycobacterium bovis: From Genotyping to Genome Sequencing

Microorganisms, 2020
Mycobacterium bovis is the main pathogen of bovine, zoonotic, and wildlife tuberculosis. Despite the existence of programs for bovine tuberculosis (bTB) control in many regions, the disease remains a challenge for the veterinary and public health sectors,
A. M. Guimarães, C. K. Zimpel
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparison of sequencing-based and array-based genotyping platforms for genomic prediction of maize hybrid performance

Crop Journal, 2023
Genomic selection (GS) is a powerful tool for improving genetic gain in maize breeding. However, its routine application in large-scale breeding pipelines is limited by the high cost of genotyping platforms.
Guangning Yu, Yanru Cui, Yuxin Jiao, Kai Zhou, Xin Wang, Wenyan Yang, Yiyi Xu, Kun Yang, Xuecai Zhang, Pengcheng Li, Zefeng Yang, Yang Xu, Chenwu Xu   +12 more
doaj   +1 more source

Improved Imputation of Common and Uncommon Single Nucleotide Polymorphisms (SNPs) with a New Reference Set [PDF]

, 2011
Statistical imputation of genotype data is an important technique for analysis of genome-wide association studies (GWAS). We have built a reference dataset to improve imputation accuracy for studies of individuals of primarily European descent using ...
Amy Hutchinson, Ann W. Hsing, Brian E. Henderson, Charles C. Chung, Christopher M. Haiman, Daniel Stram, Demetrius Albanes, Jarmo Virtamo, Jennifer L. Stone, Joshua Sampson, Kevin Jacobs, Lauren R. Teras, Margaret Tucker, Mark P. Purdue, Meredith Yeager, Michael A. Eberle, Nilanjan Chatterjee, Phil Taylor, Sonja I. Berndt, Stephen Chanock, Susan M. Gabstur, W. Ryan Diver, Xiang Deng, Zhaoming Wang   +23 more
core   +2 more sources

Evaluation of Cotton Genotypes Through the Selection Index Technique

IOP Conference Series: Earth and Environmental Science, 2023
Abstract Eight upland cotton genotypes introduced from different origins (BA440, FLASH, EDESSA, SPERO, IK259, W888, MONTANA and CANDIA) in addition to the two local cultivars (Coker 310 and Lachata) were cultivated on April 22 and 23, 2022 in the Rahmaniyah region at levels (0, 1, 2, and 3 g/liter). l) of nano-chelated NPK 20-20-20 under
Abdullah Moayad Omar, Khalid Mohammed Dawod Al-Zubaidy, Muhammed Subhi Al-Taweel   +2 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Privacy in the Genomic Era [PDF]

, 2015
Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highly-detailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including personalized ...
Ayday, Erman, Clayton, Ellen W., Fellay, Jacques, Gunter, Carl A., Hubaux, Jean-Pierre, Malin, Bradley A., Naveed, Muhammad, Wang, XiaoFeng   +7 more
core   +4 more sources