Results 81 to 90 of about 153,555 (331)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

RHD genotyping by allele specific “Loop-mediated isothermal DNA Amplification”

Bioingeniøren, 2014
Background: The “Rh” cluster, with its main antigen D, is the most important blood group system after “ABO”. Because anti-D antibodies can cause hemolytic disease of the fetus and newborn as well as hemolytic transfusion reactions, phenotyping for RhD is
Thomas Hundhausen, Nancy Lacsamana, Uraiwan Tedenes, Audun Slettan   +3 more
doaj  

Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability [PDF]

, 2013
Background: The need for new malaria surveillance tools and strategies is critical, given improved global malaria control and regional elimination efforts.
Abdullah S Ali, Anders Björkman, Andreas Mårtensson, Berit Aydin-Schmidt, Delér Shakely, DS Ishengoma, E Kamau, G Froberg, G Holmgren, G Snounou, J Hwang, José P Gil, L Cnops, LC Okell, Louise Jörnhagen, Max Petzold, MI Veiga, Mwinyi I Msellem, N Steenkeste, Pedro E Ferreira, RN Price, S Bereczky, S Dahlstrom, SA Greenspoon, SE Shokoples, Ulrika Morris, V Veron   +26 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Genotyping for platelet‐specific antigens: techniques for the detection of single nucleotide polymorphisms [PDF]

Vox Sanguinis, 2002
Accurate typing of patients for platelet‐specific (human platelet) antigens (HPA) is required in several different clinical situations, and blood services need to maintain panels of HPA‐typed apheresis platelet donors and whole‐blood donors to support HPA alloimmunized patients.
Paul Metcalfe, G. Cavanagh, Andre C. Schuh, C. M. Hurd, Willem H. Ouwehand, Willem H. Ouwehand, Willem H. Ouwehand   +6 more
openaire   +2 more sources

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Genomic Characterization of the Vaccinal Strain of Mycobacterium Avium Subspecies Paratuberculosis (MAP) 316F by MIRU-VNTR

Medical Laboratory Journal, 2015
Background and Objective: Paratuberculosis is a chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). this study aimed to characterize the genome of the MAP 316F strain.
Zahra Ebrahim, Keyvan Tadayon, Nader Mosavari   +2 more
doaj  

Smart breeding driven by advances in sequencing technology

Modern Agriculture, 2023
Crop breeding has undergone numerous advancements throughout history with the next revolution being uncertain. This review provides an overview of breeding techniques from traditional selective breeding and crossbreeding to modern breeding based on ...
Chenji Zhang, Sirong Jiang, Yangyang Tian, Xiaorui Dong, Jianjia Xiao, Yanjie Lu, Tiyun Liang, Hongmei Zhou, Dabin Xu, Han Zhang, Ming Luo, Zhiqiang Xia   +11 more
doaj   +1 more source

Microsatellite typing of avian clinical and environmental isolates of Aspergillus fumigatus [PDF]

, 2011
Aspergillosis is one of the most common causes of death in captive birds. Aspergillosis in birds is mainly caused by Aspergillus fumigatus, a ubiquitous and opportunistic saprophyte.
Beernaert, Lies, Dorrestein, Gerry M, Haesebrouck, Freddy, Klaassen, Corné HW, Martel, An, Pasmans, Frank, Van Waeyenberghe, Lieven, Vercammen, Francis, Verstappen, Frank   +8 more
core   +3 more sources

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source