Results 141 to 150 of about 161,407 (266)

Magnesium Enhances Immune Clearance of P. gingivalis in Macrophages by Suppressing MCU‐Mediated Mitochondrial Calcium Overload

Cell Proliferation, EarlyView.
Magnesium restores macrophage clearance of P. gingivalis by inhibiting MCU‐mediated calcium overload. P. gingivalis is mainly phagocytosed by macrophages but escapes intracellular clearance via MCU‐mediated mitochondrial and cytosolic Ca2+ overload in periodontitis. The persistent P.
Dao‐Kun Deng, Meng‐Jie Su, Min‐Yi Zhang, Yu‐Jie Tan, Wenyao Kongling, Hong‐Yu Wang, Mei Xu, Shi‐Yu Liu, Xiao‐Tao He, Fa‐Ming Chen, Bei‐Min Tian, Xuan Li   +11 more
wiley   +1 more source

One Model to Dose Them All: A Population Pharmacokinetic Model for Multiple Aminoglycosides Across the Human Lifespan. [PDF]

J Clin Pharmacol
Tong DMH, Faldasz JD, Keizer RJ, Hughes JH.   +3 more
europepmc   +1 more source

Pronounced Reductions in Plasma Citrulline Indicate Severe Intestinal Mucosal Barrier Injury During Induction Therapy for Pediatric Acute Myeloid Leukemia

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Pediatric acute myeloid leukemia (AML) chemotherapy regimens are frequently burdened by fever episodes, systemic inflammation and bloodstream infections (BSI). Mucosal barrier injury may contribute to these complications, but its role in childhood AML remains uninvestigated.
Carla Warley Kjær, Maria Ebbesen Sørum, Silvia De Pietri, Claus Moser, Malene Johanne Petersen, Marianne Hoffmann, Henrik Hasle, Sarah Weischendorff, Klaus Müller   +8 more
wiley   +1 more source

IL-27 neutralization with and without antibiotics as an approach to prevent and treat neonatal sepsis. [PDF]

JCI Insight
Annamanedi M, Povroznik JM, Arevalo-Marcano S, Robinson CM.   +3 more
europepmc   +1 more source

Long‐term outcome of a non‐reducible congenital atlanto‐occipital subluxation in a warmblood foal

Equine Veterinary Education, EarlyView.
Summary An 11‐day‐old warmblood colt was referred to the Large Animal Teaching Hospital, University of Copenhagen, for further investigation of a stiff neck and lateral deviation of the poll, with suspicion of a congenital cervical vertebral abnormality.
D. M. T. Adler, S. Hansen, L. Rasmussen, S. Jacobsen   +3 more
wiley   +1 more source

Daptomycin Overcomes <i>Listeria monocytogenes</i> Persister Cells Through Strain-Dependent Efficacy and clpP-Mediated Stress Response. [PDF]

Infect Drug Resist
Zeinivand Y, Pakzad I, Asadinezhad M, Omidi N, Sadeghi Kalani B.   +4 more
europepmc   +1 more source

Surgical removal of a perirectal melanoma through sphincterotomy and rectal wall resection in a horse

Equine Veterinary Education, EarlyView.
Summary Melanomas are among the most frequent neoplasms in grey horses. Deep perirectal melanomas, however, are uncommon and challenging to excise due to their proximity to the peritoneal reflection. This report describes the successful standing removal of a large (16 × 8 × 6 cm) perirectal melanoma firmly adherent to the dorsal rectal wall in a 19 ...
R. Becker, C. Koch, M. de Preux
wiley   +1 more source

Target-oriented synthesis of benzoquinoline-embedded candidates: antimicrobial potential and <i>in silico</i> insights. [PDF]

RSC Adv
El-Helw EAE, El-Naggar AM, Kamal M, El-Masry HM, Ghareeb EA.   +4 more
europepmc   +1 more source

Updates on intra‐articular corticosteroid administration in horses

Equine Veterinary Education, EarlyView.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner, L. Bass, C. Kawcak, L. V. Schnabel, K. L. Hallowell, L. M. Pezzanite   +5 more
wiley   +1 more source

Pseudomonas aeruginosa Impairs Mitochondrial Function During Infection of Corneal Epithelial Cells. [PDF]

Invest Ophthalmol Vis Sci
Ayilam Ramachandran R, Abdallah JT, Blanton AM, Rehman M, Baniasadi H, Robertson DM.   +5 more
europepmc   +1 more source