Results 41 to 50 of about 250,832 (305)

Protective Effect of Neutral Electrolyzed Saline on Gentamicin-Induced Nephrotoxicity: Evaluation of Histopathologic Parameters in a Murine Model

Medicina, 2023
Background and Objectives: Gentamicin (GM) is a nephrotoxic aminoglycoside. Neutral electrolyzed saline (SES) is a compound with anti-inflammatory, antioxidant, and immunomodulatory properties.
Nomely S. Aurelien-Cabezas, Brenda A. Paz-Michel, Ivan Jacinto-Cortes, Osiris G. Delgado-Enciso, Daniel A. Montes-Galindo, Ariana Cabrera-Licona, Sergio A. Zaizar-Fregoso, Juan Paz-Garcia, Gabriel Ceja-Espiritu, Valery Melnikov, Jose Guzman-Esquivel, Iram P. Rodriguez-Sanchez, Margarita L. Martinez-Fierro, Ivan Delgado-Enciso   +13 more
doaj   +1 more source

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum [PDF]

, 2017
In vitro models that mimic in vivo host-pathogen interactions are needed to evaluate candidate drugs that inhibit bacterial virulence traits. We established a new approach to study Pseudomonas aeruginosa biofilm susceptibility on biotic surfaces, using a
Coenye, Tom, Crabbé, Aurélie, Davis, Richard, De La Fuente-Nùñez, César, Hancock, Robert EW, Ledesma, Maria A, Liu, Yulong, Matthijs, Nele, Nickerson, Cheryl A., Rigole, Petra, Sarker, Shameema, Van Houdt, Rob   +11 more
core   +1 more source

Acinetobacter baumannii Sequence Types Harboring Genes Encoding Aminoglycoside Modifying Enzymes and 16SrRNA Methylase; a Multicenter Study from Pakistan

Infection and Drug Resistance, 2020
Mohsin Khurshid,1,2 Muhammad Hidayat Rasool,2 Usman Ali Ashfaq,3 Bilal Aslam,2 Muhammad Waseem,2 Muhammad Akhtar Ali,4 Ahmad Almatroudi,5 Farhan Rasheed,6 Muhammad Saeed,2 Qinglan Guo,1 Minggui Wang1 1Institute of Antibiotics, Huashan Hospital, Fudan ...
Khurshid M, Rasool MH, Ashfaq UA, Aslam B, Waseem M, Ali MA, Almatroudi A, Rasheed F, Saeed M, Guo Q, Wang M   +10 more
doaj  

Erythropoietin; bright future and new hopes for an old drug [PDF]

Journal of Nephropathology, 2012
Recent publications have suggested renoprotective actions for erythropoietin in certain models of acute kidney injury. In a study by Rafieian-Kopaei et al., the effects of erythropoietin on amelioration of gentamicin-induced renal toxicity was ...
Mehri Kadkhodaee
doaj   +1 more source

National variation in prophylactic antibiotic use for elective primary total joint replacement: an analysis of guidelines across hospitals and trusts in the UK

Bone & Joint Open, 2023
Aims: Prophylactic antibiotic regimens for elective primary total hip and knee arthroplasty vary widely across hospitals and trusts in the UK. This study aimed to identify antibiotic prophylaxis regimens currently in use for elective primary arthroplasty
Ahmed Mabrouk, Alexander Abouharb, Gabriel Stewart, Jeya Palan, Hemant Pandit   +4 more
doaj   +1 more source

Characterizing and Genetically Modifying Oscillatoria to Degrade BPA [PDF]

, 2017
Bisphenol A (BPA) is becoming an increasing environmental concern. It is a hormone disruptor, and its presence in natural waterways causes some aquatic species to experience problems in growth, reproduction, and development.
Long, Grace
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Antimicrobial properties and substantivity of gentamicin, amoxicillin and metronidazole (GAM) antibiotic solution with chitosan as a root canal irrigant – A preliminary study

Journal of Pharmacy and Bioallied Sciences, 2023
Irrigation is one of the steps that is very crucial in a high-quality endodontic treatment. Hence, irrigant with good substantivity is essential which must not only be effective for the dissolution of the organic tissues but also effectively eliminate ...
Keyura Parakh, Raghavendra M Shetty, Sunaina Shetty, Vijay Desai, Shishir Shetty, Anas Al Jadaa, Sonal Jain, Venkataramana Vannala   +7 more
doaj   +1 more source

Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]

, 2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A., Di Leonardo A., Lentini L., Melfi R., Pace A., Pibiri I., Tutone M.   +6 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source