Results 31 to 40 of about 171,280 (266)

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Impact of Dosing Intervals on Activity of Gentamicin and Ticarcillin Against Pseudomonas aeruginosa in Granulocytopenic Mice [PDF]

, 1983
The influence of dosing intervals on the activity of gentamicin and ticarcillin against Pseudomonas aeruginosa was studied in vivo. Granulocytopenic mice infected with P.
Vastola, A. P., Craig, W. A., Feller, C., W. A. Craig, Gerber, A. U., Brugger, H.-P., J. Brandel, C. Feller, A. U. Gerber, A. P. Vastola, Brandel, J., H.- P. Brugger   +11 more
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Multifunctional Wound Dressings: Melt Electrowritten Scaffolds Combined With Phytotherapeutic Composite Hydrogels

Advanced Materials Interfaces, EarlyView.
ABSTRACT The increasing prevalence of impaired wounds, caused mainly by diabetes or aging, alongside the growing number of bacterial infections, indicates the need for alternative tissue engineering solutions. In this study, we developed novel melt electrowritten (MEW) polycaprolactone (PCL) scaffolds incorporated with an alginate (Alg)–gelatin (Gel ...
Andrada‐Ioana Damian‐Buda, Aldo Roberto Boccaccini, Irem Unalan   +2 more
wiley   +1 more source

Effect of Three Different Amino Acids Plus Gentamicin Against Methicillin-Resistant Staphylococcus aureus [PDF]

, 2023
Juan Guo,1,* Zhiyu Pan,1,* Lvyuan Fan,1 Yilin Zhong,1 Rui Pang,2 Yubin Su1 1Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, MOE Key Laboratory of Tumor Molecular Biology, Guangdong ...
Pan Z, Pang R, Guo J, Fan L, Zhong Y, Su Y   +5 more
core  

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Efficacy of neutral and negatively charged liposome-loaded gentamicin on planktonic bacteria and biofilm communities [PDF]

, 2017
Moayad Alhariri,1 Majed A Majrashi,2 Ali H Bahkali,3 Faisal S Almajed,4 Ali O Azghani,5 Mohammad A Khiyami,2 Essam J Alyamani,2 Sameera M Aljohani,6 Majed A Halwani1 1Nanomedicine Department, King Abdullah International Medical Research Center (KAIMRC),
Khiyami MA, Alyamani EJ, Bahkali AH, Halwani MA, Almajed FS, Azghani AO, Aljohani SM, Majrashi MA, Alhariri M   +8 more
core  

The structural and functional basis of GenB2 isomerase activity from gentamicin biosynthesis [PDF]

Aminoglycosides are important antibiotics used to treat severe infections caused mainly by gram-negative bacteria. Gentamicin is an aminoglycoside, and despite its toxicity, is clinically used to treat several pulmonary and urinary infections.
Yuan, Li, Yuhui , Sun, Gabriel, de Oliveira, Jiahai , Zhou, Peter, Leadlay, Priscila, Bury, Fanglu, Huang, Finian, Leeper, Natália, Araújo, Marcio, Dias   +9 more
core   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use? [PDF]

, 2016
Arash Moghaddam,1 Viola Graeser,1 Fabian Westhauser,1 Ulrike Dapunt,1 Till Kamradt,1 Stefan M Woerner,2 Gerhard Schmidmaier1 1HTRG – Heidelberg Traume Research Group Center for Orthopedics, Trauma and Spinal Cord Injury, University Hospital ...
Westhauser F, Dapunt U, Woerner SM, Graeser V, Kamradt T, Schmidmaier G, Moghaddam A   +6 more
core  

Gentamicin induces calciuresis by blocking TRPV5 [PDF]

, 2022
BACKGROUND: Treatment with the aminoglycoside antibiotic gentamicin can be associated with severe side effects including renal Ca2+ wasting. The underlying mechanism is unknown but proposed to involve activation of the Ca2+ -sensing receptor (CaSR) in ...
Alexander, R. T., Dimke, Henrik; id_orcid, Ferreira, Patrícia G., Lee, Justin J., van Megen, Wouter H., Wolf, Matthias T., An, Sung Wan, Beggs, Megan R.   +7 more
core   +1 more source