Results 171 to 180 of about 1,607 (189)

Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage

Food and Chemical Toxicology, 2013
Gamma ray irradiation triggers DNA damage and apoptosis of proliferating stem cells and peripheral immune cells, resulting in the destruction of intestinal crypts and lymphoid system. Geraniin is a natural compound extracts from an aquatic plant Nymphaea tetragona and possesses good antioxidant property.
So Jin, Bing, Danbee, Ha, Min Ju, Kim, Eunjin, Park, Ginnae, Ahn, Dae Seung, Kim, Ryeo Kyeong, Ko, Jae Woo, Park, Nam Ho, Lee, Youngheun, Jee   +9 more
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ChemInform Abstract: GERANIIN, A NEW ELLAGITANNIN FROM GERANIUM THUNBERGII

Chemischer Informationsdienst, 1977
AbstractDas Geraniin (I), dessen Struktur ermittelt wurde, wurde aus Geranium thunbergii isoliert.
T. OKUDA, T. YOSHIDA, H. NAYESHIRO
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Geraniin targeting CaMKK2 inhibits lipid accumulation in 3T3-L1 adipocytes by suppressing lipogenesis

Chemico-Biological Interactions, 2023
Obesity has become a worldwide burden and is associated with severe medical complications. Geraniin is a polyphenolic compound that has a wide range of bioactive properties. There is also evidence to support its pharmacological effects on improving lipid accumulation and obesity.
Ji Li, Xuedong Wang, Xiangyu Meng, Xin Zhou, Han Huang, Yi Feng, Yujie Fu, Xinxin Liu, Bo Yu   +8 more
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Physicochemical Properties, Permeability and Bioavailability of Geraniin and Geraniin-Phospholipid Complex

2017
Geraniin has been credited with a range of bioactive properties and therefore merits greater research into its potential pharmaceutical, nutraceutical and cosmetic applications. To clarify its functionalities and to explore future applications, a more comprehensive understanding of geraniin; its physiochemical, permeability, bioavailability and ...
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Abstract B173: Inhibition of the Mdm2-p53 interaction by geraniin.

Molecular Cancer Therapeutics, 2011
Abstract Damage by UV, IR, chemical agents and other stresses causes cell cycle arrest and induces DNA repair in eukaryotic cells while severe DNA damage invokes apoptosis. Cell cycle checkpoint signaling pathways are responsible for cell cycle arrest and decisions about cell survival or apoptosis.
Daisuke Tatsuda, Masatomi Iijima, Takashi Kitayama, Isao Momose, Akio Nomoto   +4 more
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Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats

Bioorganic & Medicinal Chemistry Letters, 2015
In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal ...
Yiqin, Lu, Bo, He, Xiaochao, Zhang, Renhua, Yang, Shude, Li, Bo, Song, Yue, Zhang, Yu, Yun, Hongli, Yan, Peng, Chen, Zhiqiang, Shen   +10 more
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Identification of the ellagitannin geraniin as a novel Hsp90 inhibitor

Planta Medica, 2013
Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone assisting the proper protein folding and assembly, and targeting misfolded proteins to the proteolytic degradation.1 - 3 Inhibition of the Hsp90 activity incapacitates simultaneously multiple client proteins, resulting in a blockade of multiple signaling pathways and, ultimately ...
A. Vassallo, VACCARO, MARIACARMELA, M. Vasaturo, LEONE, ANTONIETTA, DAL PIAZ, FABRIZIO, DE TOMMASI, Nunziatina   +5 more
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Effects of geraniin on osteoclastic bone resorption and matrix metalloproteinase-9 expression

Bioorganic & Medicinal Chemistry Letters, 2013
In our previous studies, geraniin was reported to have a preventive effect in the rat model of tretinoin-induced osteoporosis. However, whether geraniin exhibits an inhibitory effect on bone resorption or on MMP-9 expression is not yet known. We present here our novel findings from in vitro experiments that geraniin (a) decreases the number of mature ...
Bo, He, Min, Hu, Shu-De, Li, Xue-Ting, Yang, Yi-Qin, Lu, Jian-Xing, Liu, Peng, Chen, Zhi-Qiang, Shen   +7 more
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Geraniin, a Hydrolyzable Tannin fromNymphaea tetragonaGeorgi (Nymphaeaceae)

Bioscience, Biotechnology, and Biochemistry, 1993
Geraniin, an antimicrobial hydrolyzable tannin against fish pathogenic bacteria, was isolated from Nymphaea tetragona (Nymphaeaceae).
Hideyuki Kurihara, Jun Kawabata, Mutsuo Hatano   +2 more
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Induction of apoptosis in human gastric carcinoma cell by Geraniin

2010 3rd International Conference on Biomedical Engineering and Informatics, 2010
Aim: To study the anti-tumour effect of Geraniin isolated from Agrimonia pilosa ledeb. Methods: MTT was used to study anti-tumor effect of Geraniin in vitro. Morphological observation of the cells was completed by fluorescence microscope. The effect of Gerannin on cell apoptosis in human gastric carcinoma SGC-7901 cells was studied by flow cytometry ...
Bao Qing Wang, Zhe Xiong Jin
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