Results 131 to 140 of about 2,762 (157)

Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

Il Farmaco, 2004
Stable analogues of geranylgeranyl diphosphate, possessing 3-(phosphono)propionamido moieties in the place of the metabolically unstable diphosphate portion, were prepared and submitted to prenyltransferase (GGTase and FTase) inhibition assays. In one case, an excellent GGTase inhibitory activity was obtained (IC(50) = 39 nM), accompanied by a certain ...
MINUTOLO, FILIPPO, ASSO V, BERTINI, SIMONE, BETTI, LAURA, GERVASI G, GHILARDI E, GIANNACCINI, GINO, PLACANICA, GIORGIO, PROTA G, RAPPOSELLI, SIMONA, MACCHIA, MARCO   +10 more
openaire   +3 more sources

Phosphonomethylphosphorylmethyl(oxy)‐Analogues of Geranylgeranyl Diphosphate as Stable and Selective Geranylgeranyl Protein Transferase Inhibitors.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Marco Macchia, et al. et al.
openaire   +1 more source

Rab geranylgeranyl transferase

1995
Abstract CAAX GGTase, also known as GGTase-I, is composed of twotightly coupled subunits, designated a. and 13 (Moomawand Casey 1992; Yokoyama and Gelb 1993). The a-subunitis identical to the a-subunit of FTase as determined byimmunological studies (Sea bra et al. 1991; Kohl et al. 1991;Moomaw and Casey 1992), cDNA cloning and expression(
Miguel C Seabra, Michael S Brown, Joseph L Goldstein   +2 more
openaire   +1 more source

Erythropoietin Receptor Signal Transduction Requires Protein Geranylgeranylation

The Journal of Pharmacology and Experimental Therapeutics, 2006
Erythropoietin (Epo) acts through the erythropoietin receptor, a member of the type-1 cytokine receptor family, to influence survival, proliferation, and differentiation of erythroid progenitors. Epo stimulation of factor-dependent 32D cells results in phosphorylation of many proteins, including Janus kinase (Jak) 2, signal transducer and activator of ...
Sumaya N, Hamadmad, Matthew K, Henry, Raymond J, Hohl   +2 more
openaire   +2 more sources

Geranylgeranyl Diphosphate Synthase: An Emerging Therapeutic Target

Clinical Pharmacology & Therapeutics, 2011
Proteins modified post-translationally by geranylgeranylation have been implicated in numerous cellular processes related to human disease. In recent years, the study of protein geranylgeranylation has advanced tremendously in both cellular and animal models.
A J, Wiemer, D F, Wiemer, R J, Hohl
openaire   +2 more sources

Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi

Applied Microbiology and Biotechnology, 2009
Based on comparative amino-acid sequence alignment of geranylgeranyl diphosphate (GGPP) synthase from filamentous fungi, degenerated oligonucleotide primers were designed for searching GGPP synthase gene(s) in entomopathogenic fungi. Polymerase chain reaction with the designed primers amplified GGPP synthase homologues from five representative ...
Suthitar, Singkaravanit, Hiroshi, Kinoshita, Fumio, Ihara, Takuya, Nihira   +3 more
openaire   +2 more sources

Stable Propylphosphonic Acid Analogues of Geranylgeranyl Diphosphate Possessing Inhibitory Activity on Geranylgeranyl Protein Transferase.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Macro Macchia, et al. et al.
openaire   +1 more source

Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate

The Journal of Pharmacology and Experimental Therapeutics, 2011
Multiple studies have implicated the depletion of isoprenoid biosynthetic pathway intermediates in the induction of autophagy. However, the exact mechanism by which isoprenoid biosynthesis inhibitors induce autophagy has not been well established. We hypothesized that inhibition of farnesyl diphosphate synthase (FDPS) and geranylgeranyl diphosphate ...
Brian M, Wasko, Amel, Dudakovic, Raymond J, Hohl   +2 more
openaire   +2 more sources

CAAX geranylgeranyl transferase

1995
Abstract GGTase, also known as GGTase-I, is composed of two tightly coupled subunits, designated α and β (Moomawand Casey 1992; Yokoyama and Gelb 1993). The a-subunit is identical to the a-subunit of FTase as determined by immunological studies (Seabra et al. 1991; Kohl et al.
Miguel C Seabra, Joseph L Goldstein, Michael S Brown   +2 more
openaire   +1 more source

A role for geranylgeranylation in interleukin‐1β secretion

Arthritis & Rheumatism, 2006
AbstractObjectiveMevalonate kinase deficiency (MKD) is an autosomal‐recessive disorder characterized by recurring episodes of inflammation. MK catalyzes the phosphorylation of mevalonic acid, which is an early step in isoprenoid biosynthesis. The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or ...
Mandey, Saskia H. L., Kuijk, Loes M., Frenkel, Joost, Waterham, Hans R.   +3 more
openaire   +2 more sources