Results 151 to 160 of about 3,218 (202)

Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics. [PDF]

Mol Cancer
Xu M, Xu B.
europepmc   +1 more source

Metabolic remodeling and immune evasion in glioblastoma: a focus on serine and lipid networks. [PDF]

Front Oncol
Jiang D, Wang C, Zhao Y, Li Y.
europepmc   +1 more source

Myeloid PGGT1B Deficiency Promotes Psoriasiform Dermatitis by Promoting the Secretion of Inflammatory Factors. [PDF]

Int J Mol Sci
Yu S, Long F, Wei X, Gu H, Hao Z.
europepmc   +1 more source

Protein lipidation in health and disease: molecular basis, physiological function and pathological implication. [PDF]

Signal Transduct Target Ther
Yuan Y, Li P, Li J, Zhao Q, Chang Y, He X.   +5 more
europepmc   +1 more source

Serum CDC42 level change during abiraterone plus prednisone treatment and its association with prognosis in metastatic castration-resistant prostate cancer patients. [PDF]

Discov Oncol
Ma Y, Cao Z, Zhang J, Zhu X, Zhao Z, Xiong J.   +5 more
europepmc   +1 more source

Mononuclear phagocyte morphological response to chemoattractants is dependent on geranylgeranyl pyrophosphate.

Am J Physiol Endocrinol Metab
Krauklis SA, Hussain J, Murphy KM, Dray EL, Ousley CG, Justyna K, Distefano MD, Steelman AJ, McKim DB.   +8 more
europepmc   +1 more source

Geranylgeranyl Diphosphate-Based Inhibitors of Post-Translational Geranylgeranylation of Cellular Proteins

Journal of Medicinal Chemistry, 1996
A novel series of stable analogs of geranylgeranyl diphosphate (GGdP) are described in which the biologically labile diphosphate moiety of GGdP is replaced by portions that can act as stable isosters. The compounds inhibited the geranylgeranyltransferase activity in whole PC-3 prostate cancer cells, as determined by the inhibition of post-translational
MACCHIA, MARCO, JANNITTI N, GERVASI G, DANESI, ROMANO   +3 more
openaire   +4 more sources

A role for geranylgeranylation in interleukin‐1β secretion

Arthritis & Rheumatism, 2006
AbstractObjectiveMevalonate kinase deficiency (MKD) is an autosomal‐recessive disorder characterized by recurring episodes of inflammation. MK catalyzes the phosphorylation of mevalonic acid, which is an early step in isoprenoid biosynthesis. The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or ...
Mandey, Saskia H. L., Kuijk, Loes M., Frenkel, Joost, Waterham, Hans R.   +3 more
openaire   +3 more sources

Control of antiviral innate immune response by protein geranylgeranylation

Science Advances, 2019
The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection. However, how MAVS signaling is controlled to eradicate virus while preventing self-destructive inflammation remains obscure ...
Shigao Yang, Alfred T Harding, Catherine Sweeney   +2 more
exaly   +4 more sources

Ultrastructural and Biochemical Evidence of Apoptosis Induced by a Novel Inhibitor of Protein Geranylgeranylation in Human MIA PaCa-2 Pancreatic Cancer Cells

Ultrastructural Pathology, 1998
Analogs of geranylgeranyl diphosphate (GGdP) have been demonstrated to inhibit the geranylgeranylation of proteins, producing cytotoxic activity in human prostate cancer cells.
Marco Gesi, A Pellegrini, Paola Soldani   +2 more
exaly   +2 more sources