Results 161 to 170 of about 3,218 (202)

Geranylgeranylation of Rab proteins

Biochemical Society Transactions, 1996
L, Desnoyers, J S, Anant, M C, Seabra
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Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

Leukemia, 2001
Lovastatin is an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the major regulatory enzyme of the mevalonate pathway. We have previously reported that lovastatin induces a significant apoptotic response in human acute
W Wei-Lynn Wong, Jim Dimitroulakos, Linda Z Penn   +2 more
exaly   +2 more sources

Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate

The Journal of Pharmacology and Experimental Therapeutics, 2011
Multiple studies have implicated the depletion of isoprenoid biosynthetic pathway intermediates in the induction of autophagy. However, the exact mechanism by which isoprenoid biosynthesis inhibitors induce autophagy has not been well established. We hypothesized that inhibition of farnesyl diphosphate synthase (FDPS) and geranylgeranyl diphosphate ...
Brian M, Wasko, Amel, Dudakovic, Raymond J, Hohl   +2 more
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Geranylgeranylation

, 2011
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Geranylgeranylation

, 2008
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Inhibitors of Protein: Geranylgeranyl Transferases

Current Medicinal Chemistry, 2006
The enzyme protein:geranylgeranyl transferase-1 (PGGT-1 or GGTase-I) catalyzes the geranylgeranylation of cysteine residues near the C-termini of a variety of proteins, including most monomeric GTP binding precursor proteins belonging to the Rho, Rac and Rap subfamilies.
Farid, El Oualid, Louis H, Cohen, Gijs A, van der Marel, Mark, Overhand   +3 more
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Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

Il Farmaco, 2004
The diphosphate moiety of geranylgeranyldiphosphate (GGdP) was replaced with metabolically and hydrolytically stable analogous polar portions, in an attempt to obtain new geranylgeranyltransferase (GGTase) inhibitors, which could also be selective over congener enzyme farnesyltransferase (FTase).
MINUTOLO, FILIPPO, M. ANTONELLO, S. BARONTINI, BERTINI, SIMONE, BETTI, LAURA, DANESI, ROMANO, G. GERVASI, GIANNACCINI, GINO, C. PAPI, PLACANICA, GIORGIO, RAPPOSELLI, SIMONA, MACCHIA, MARCO   +11 more
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Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

Il Farmaco, 2004
Stable analogues of geranylgeranyl diphosphate, possessing 3-(phosphono)propionamido moieties in the place of the metabolically unstable diphosphate portion, were prepared and submitted to prenyltransferase (GGTase and FTase) inhibition assays. In one case, an excellent GGTase inhibitory activity was obtained (IC(50) = 39 nM), accompanied by a certain ...
MINUTOLO, FILIPPO, ASSO V, BERTINI, SIMONE, BETTI, LAURA, GERVASI G, GHILARDI E, GIANNACCINI, GINO, PLACANICA, GIORGIO, PROTA G, RAPPOSELLI, SIMONA, MACCHIA, MARCO   +10 more
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Phosphonomethylphosphorylmethyl(oxy)‐Analogues of Geranylgeranyl Diphosphate as Stable and Selective Geranylgeranyl Protein Transferase Inhibitors.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Marco Macchia, et al. et al.
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Rab geranylgeranyl transferase

1995
Abstract CAAX GGTase, also known as GGTase-I, is composed of twotightly coupled subunits, designated a. and 13 (Moomawand Casey 1992; Yokoyama and Gelb 1993). The a-subunitis identical to the a-subunit of FTase as determined byimmunological studies (Sea bra et al. 1991; Kohl et al.
Miguel C Seabra, Michael S Brown, Joseph L Goldstein   +2 more
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