Results 101 to 110 of about 24,196 (383)

Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review [PDF]

, 2016
Notwithstanding the peculiar sensitivity to cisplatin-based treatment, resulting in a very high percentage of cures even in advanced stages of the disease, still we do not know the biological mechanisms that make Testicular Germ Cell Tumor (TGCT) "unique"
Ametrano, Gianluca, Berretta, Massimiliano, Botti, Gerardo, Cappuccio, Francesca, Caraglia, Michele, Castaldo, Luigi, Cavaliere, Carla, Ciliberto, Gennaro, Conteduca, Vincenza, D'Aniello, Carmine, De Falco, Francesco, De Giorgi, Ugo, Di Franco, Rossella, Facchini, Gaetano, Lamantia, Elvira, Maiolino, Piera, Malzone, Gabriella, Montanari, Micaela, Montella, Maurizio, Muto, Paolo, Nocerino, Flavia, Pepe, Maria Filomena, Perdonà, Sisto, Piscitelli, Raffaele, Quagliariello, Vincenzo, Romano, Francesco Jacopo, Rossetti, Sabrina, Schepisi, Giuseppe, Vanacore, Daniela, Veneziani, Bianca Maria   +29 more
core   +1 more source

Imprinting Status of Gα_S, NESP55, and XLαs in Cell Cultures Derived from Human Embryonic Germ Cells: GNAS Imprinting in Human Embryonic Germ Cells [PDF]

Clinical and Translational Science, 2009
Abstract GNAS is a complex gene that through use of alternative first exons encodes signaling proteins Gαs and XLαs plus neurosecretory protein NESP55. Tissue‐specific expression of these proteins is regulated through reciprocal genomic imprinting in fully differentiated and developed tissue.
Janet L, Crane, Michael J, Shamblott, Joyce, Axelman, Stephanie, Hsu, Michael A, Levine, Emily L, Germain-Lee   +5 more
openaire   +2 more sources

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Embryonal carcinoma in androgen insensitivity syndrome

Indian Journal of Medical and Paediatric Oncology, 2011
Embryonal cell carcinoma is a rare clinical entity. We report a case of a 20-year-old patient who presented with lump lower abdomen for last two months with primary amenorrhea and poorly developed secondary sexual characteristics.
Debabrata Barmon, Amal Chandra Kataki, J D Sharma, Rahman Hafizur   +3 more
doaj   +1 more source

Serum free culture and characterization of human embryonic germ cells [PDF]

Cell Research, 2008
Many proteins and growth factors in serum play important roles in the propagation of embryonic stem (ES) cells. But there are some disadvantages in using the serum to culture ES cells. We examined the effects of a chemically-defined culture system knock-out serum replacement (KSR) in the absence of FBS on the growth and differentiation of human ...
JinLian Hua, Hai-sheng Yu, Sheng Liu, Zhongying Dou   +3 more
openaire   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

PD-L1 expression in testicular germ cell tumors undergoing spontaneous regression

Biomolecules & Biomedicine
Spontaneous regression of testicular germ cell tumors is a well-known phenomenon; however, the precise mechanisms of spontaneous regression are still unknown.
Ivan Novak, Miroslav Tomić, Denis Mulabdić, Ivan Pezelj, Slaven Čiček, Igor Tomašković, Nino Sinčić, Božo Krušlin, Monika Ulamec   +8 more
doaj   +1 more source

Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review

Case Reports in Pathology, 2016
Adult extrarenal nephroblastoma is a very rare tumor. Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare. To our knowledge, only three cases have been reported in the English literature.
Houda Alatassi, Brittany E. O’Bryan, Jamie C. Messer, Zhenglong Wang   +3 more
doaj   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Embryonic development of any animal species is a robust series of morphogenetic events tightly controlled by molecular signals. However, the variety of developmental trajectories undertaken by different members of the same phylum suggests that normal development in each particular species might involve only a subset ...
Anastasia Kirillova, Grigory Genikhovich, Ekaterina Pukhlyakova, Adrien Demilly, Yulia Kraus, Ulrich Technau   +5 more
openaire   +2 more sources