Results 81 to 90 of about 21,086 (311)

Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Embryonic development of any animal species is a robust series of morphogenetic events tightly controlled by molecular signals. However, the variety of developmental trajectories undertaken by different members of the same phylum suggests that normal development in each particular species might involve only a subset ...
Anastasia Kirillova, Grigory Genikhovich, Ekaterina Pukhlyakova, Adrien Demilly, Yulia Kraus, Ulrich Technau   +5 more
openaire   +2 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

PD-L1 expression in testicular germ cell tumors undergoing spontaneous regression

Biomolecules & Biomedicine
Spontaneous regression of testicular germ cell tumors is a well-known phenomenon; however, the precise mechanisms of spontaneous regression are still unknown.
Ivan Novak, Miroslav Tomić, Denis Mulabdić, Ivan Pezelj, Slaven Čiček, Igor Tomašković, Nino Sinčić, Božo Krušlin, Monika Ulamec   +8 more
doaj   +1 more source

Embryonal carcinoma in androgen insensitivity syndrome

Indian Journal of Medical and Paediatric Oncology, 2011
Embryonal cell carcinoma is a rare clinical entity. We report a case of a 20-year-old patient who presented with lump lower abdomen for last two months with primary amenorrhea and poorly developed secondary sexual characteristics.
Debabrata Barmon, Amal Chandra Kataki, J D Sharma, Rahman Hafizur   +3 more
doaj   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Nephroblastoma Arising from Primary Testicular Germ Cell Tumor: A Case Report and Literature Review

Case Reports in Pathology, 2016
Adult extrarenal nephroblastoma is a very rare tumor. Nephroblastoma arising from primary testicular germ cell tumor is exceedingly rare. To our knowledge, only three cases have been reported in the English literature.
Houda Alatassi, Brittany E. O’Bryan, Jamie C. Messer, Zhenglong Wang   +3 more
doaj   +1 more source

MPSS profiling of embryonic gonad and primordial germ cells in chicken

Physiological Genomics, 2007
The massively parallel signature sequencing (MPSS) provides a greater depth of coverage than expressed sequence tag scan or microarray and provides a comprehensive expression profile. We used the MPSS technology to uncover gene expression profiling in the early embryonic gonads and primordial germ cells (PGCs) in the chicken.
Heebal, Kim, Tae Sub, Park, Woon Kyu, Lee, Sunjin, Moon, Jin Nam, Kim, Ji Hye, Shin, Jin Gyoung, Jung, Seon Duk, Lee, Sang Hyun, Park, Kyung Je, Park, Mi A, Kim, Sang Su, Shin, Tae Min, Kim, Jungrye, Nam, Yeonkyung, Kang, Jeong Mook, Lim, Jae Yong, Han   +16 more
openaire   +3 more sources

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma [PDF]

, 2017
Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. Seminomas are similar to carcinoma in situ (CIS) cells, the common precursor of type II GCCs, with regard to epigenetics and expression, while embryonal carcinomas (EC ...
Esteller, Manel, Ferreira, Humberto J., Hoffmann, Per, Hofmann, Andrea, Jostes, Sina, Kristiansen, Glen, Nettersheim, Daniel, Schneider, Simon, Schorle, Hubert, Sharma, Rakesh   +9 more
core   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source