Results 61 to 70 of about 21,086 (311)

Spermatogonial kinetics in humans [PDF]

, 2017
The human spermatogonial compartment is essential for daily production of millions of sperm. Despite this crucial role, the molecular signature, kinetic behavior and regulation of human spermatogonia are poorly understood.
Berloco, Bartolomeo P., Boitani, Carla, de Rooij, Dirk G., Di Persio, Sara, Esposito, Valentina, Fera, Stefania, Muciaccia, Barbara, Nudo, Francesco, Saracino, Rossana, Spadetta, Gustavo, Stefanini, Mario, Vicini, Elena   +11 more
core   +1 more source

Establishment of a Human Embryonic Germ Cell Line and Comparison with Mouse and Human Embryonic Stem Cells

Molecules and Cells, 2004
Human embryonic stem (ES) cells and embryonic germ (EG) cells are pluripotent and are invaluable material for in vitro studies of human embryogenesis and cell therapy. So far, only two groups have reported the establishment of human EG cell lines, whereas at least five human ES cell lines have been established.
Jong Hyuk, Park, Sun Jong, Kim, Jung Bok, Lee, Ji Min, Song, Chul Geun, Kim, Sung, Roh, Hyun Soo, Yoon   +6 more
openaire   +2 more sources

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Extragonadal germ-cell tumors – a review of the pathogenesis, histopathological findings, diagnosis and treatment [PDF]

Archives of the Balkan Medical Union, 2019
Primary extragonadal germ-cell tumors (EGCTs) are a rare group of neoplasms, that can exist anywere along the midline of the body, without the evidence of a primary gonadal tumor.
Lucian IORGA, Dragos MARCU, Ovidiu BRATU, Bogdan SOCEA, Tiberiu P. NEAGU, Simona BUNGAU, Ana Maria A. STANESCU, Camelia C. DIACONU, Dan MISCHIANU   +8 more
doaj   +1 more source

Extra-gonadal germ cell tumour – what about the testis! [PDF]

, 2011
Extra-gonadal germ cell tumours (EGGCT) are rare. Therefore further investigations of the testis is aimed at sourcing a possible primary origin of gonadal tumour. Over the years, various case series on EGGCT have been reported questioning its true nature
Christopher CKH,, Goh EH,, Johann FK,, Praveen S,, Razman J,, Zulkifli MZ,   +5 more
core  

Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review [PDF]

, 2016
Notwithstanding the peculiar sensitivity to cisplatin-based treatment, resulting in a very high percentage of cures even in advanced stages of the disease, still we do not know the biological mechanisms that make Testicular Germ Cell Tumor (TGCT) "unique"
Ametrano, Gianluca, Berretta, Massimiliano, Botti, Gerardo, Cappuccio, Francesca, Caraglia, Michele, Castaldo, Luigi, Cavaliere, Carla, Ciliberto, Gennaro, Conteduca, Vincenza, D'Aniello, Carmine, De Falco, Francesco, De Giorgi, Ugo, Di Franco, Rossella, Facchini, Gaetano, Lamantia, Elvira, Maiolino, Piera, Malzone, Gabriella, Montanari, Micaela, Montella, Maurizio, Muto, Paolo, Nocerino, Flavia, Pepe, Maria Filomena, Perdonà, Sisto, Piscitelli, Raffaele, Quagliariello, Vincenzo, Romano, Francesco Jacopo, Rossetti, Sabrina, Schepisi, Giuseppe, Vanacore, Daniela, Veneziani, Bianca Maria   +29 more
core   +1 more source

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Primary embryonal carcinoma of the prostate

Urology Case Reports
Extragonadal germ cell tumors originating in the prostate are extremely rare. Thus far, less than 20 cases were described in the literature. To our knowledge, there are no published cases of primary embryonal carcinoma of the prostate.
Milan Radovanović, Aleksa Zubelić, Veljko Šantrić, Uroš Babić, Nebojša Prijović, Predrag Nikić   +5 more
doaj   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Biology of childhood germ cell tumours, focussing on the significance of microRNAs. [PDF]

, 2014
Genomic and protein-coding transcriptomic data have suggested that germ cell tumours (GCTs) of childhood are biologically distinct from those of adulthood.
Coleman, N, Murray, MJ, Nicholson, JC
core   +2 more sources